TY - JOUR
T1 - Bortezomib-induced tumor lysis syndrome in a patient with HIV-negative plasmablastic lymphoma
AU - Lipstein, Mark
AU - O'Connor, Owen
AU - Montanari, Francesca
AU - Paoluzzi, Luca
AU - Bongero, Danielle
AU - Bhagat, Govind
PY - 2010/10
Y1 - 2010/10
N2 - Plasmablastic lymphoma (PBL) is an aggressive lymphoma classified by the World Health Organization as a subtype of diffuse large B-cell lymphoma that shares many morphologic and immunophenotypic features with multiple myeloma. It is extremely rare in immunocompetent patients. Because of the small number of patients reported, this rare lymphoma remains a poorly characterized and understood entity with presently no standard recommendations regarding the optimal treatment. Herein, we report a dramatic clinical response coupled with tumor lysis syndrome to a bortezomib-based treatment in an HIV-negative patient with refractory plasmablastic lymphoma.
AB - Plasmablastic lymphoma (PBL) is an aggressive lymphoma classified by the World Health Organization as a subtype of diffuse large B-cell lymphoma that shares many morphologic and immunophenotypic features with multiple myeloma. It is extremely rare in immunocompetent patients. Because of the small number of patients reported, this rare lymphoma remains a poorly characterized and understood entity with presently no standard recommendations regarding the optimal treatment. Herein, we report a dramatic clinical response coupled with tumor lysis syndrome to a bortezomib-based treatment in an HIV-negative patient with refractory plasmablastic lymphoma.
KW - Diffuse large B-cell lymphoma
KW - Non-Hodgkin lymphoma
KW - R-CHOP
UR - http://www.scopus.com/inward/record.url?scp=79952996426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952996426&partnerID=8YFLogxK
U2 - 10.3816/CLML.2010.n.074
DO - 10.3816/CLML.2010.n.074
M3 - Article
C2 - 21856550
AN - SCOPUS:79952996426
SN - 2152-2650
VL - 10
SP - E43-E46
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 5
ER -