Bone, inflammation, and inflammatory bowel disease

Manasi Agrawal; Shitij Arora; Jianjun Li; Rabin Rahmani; Li Sun; Adam F. Steinlauf; Jeffrey I. Mechanick; Mone Zaidi

doi:10.1007/s11914-011-0077-9

Bone, inflammation, and inflammatory bowel disease

Manasi Agrawal, Shitij Arora, Jianjun Li, Rabin Rahmani, Li Sun, Adam F. Steinlauf, Jeffrey I. Mechanick, Mone Zaidi

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

Original language	English (US)
Pages (from-to)	251-257
Number of pages	7
Journal	Current Osteoporosis Reports
Volume	9
Issue number	4
DOIs	https://doi.org/10.1007/s11914-011-0077-9
State	Published - Dec 2011
Externally published	Yes

Keywords

Bone
Bone loss
Cytokines
Inflammation
Inflammatory bowel disease
Osteoblast
Osteoclast

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11914-011-0077-9

Cite this

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title = "Bone, inflammation, and inflammatory bowel disease",

abstract = "Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.",

keywords = "Bone, Bone loss, Cytokines, Inflammation, Inflammatory bowel disease, Osteoblast, Osteoclast",

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AU - Agrawal, Manasi

AU - Arora, Shitij

AU - Li, Jianjun

AU - Rahmani, Rabin

AU - Sun, Li

AU - Steinlauf, Adam F.

AU - Mechanick, Jeffrey I.

AU - Zaidi, Mone

PY - 2011/12

Y1 - 2011/12

N2 - Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

AB - Osteoporosis is a leading cause of morbidity in patients with inflammatory bowel disease (IBD). Bone loss is an early systemic process and occurs even before clinical disease manifests. Bone disease is attributed to vitamin D deficiency, steroid use, and/or systemic inflammation. In this review, we discuss the molecular pathways of bone loss mediated by inflammatory cytokines and other mediators. Further research will hopefully clarify the mechanisms of inflammation-induced bone loss in IBD and guide effective treatment modalities.

KW - Bone

KW - Bone loss

KW - Cytokines

KW - Inflammation

KW - Inflammatory bowel disease

KW - Osteoblast

KW - Osteoclast

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JO - Current Osteoporosis Reports

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IS - 4

ER -

Bone, inflammation, and inflammatory bowel disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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