TY - JOUR
T1 - BMP signaling is required locally to pattern the dorsal telencephalic midline
AU - Hébert, Jean M.
AU - Mishina, Yuji
AU - McConnell, Susan K.
N1 - Funding Information:
We thank Mike Porter and Chris Kaznowski for outstanding technical support, John Rubenstein for thoughtful discussions, and Elizabeth Alcamo and Ami Okada for critically reading the manuscript. We are also grateful to Lubert Stryer and Bill Mobley for indispensable input. This work was supported by NIH grants MH51864 and NS12151 and a McKnight Investigator Award.
PY - 2002/9/12
Y1 - 2002/9/12
N2 - BMPs have been proposed to pattern the medial-lateral axis of the telencephalon in a concentration-dependent manner, thus helping to subdivide the embryonic telencephalon into distinct forebrain regions. Using a CRE/loxP genetic approach, we tested this hypothesis by disrupting the Bmpr1a gene in the telencephalon. In mutants, BMP signaling was compromised throughout the dorsal telencephalon, but only the most dorsalmedial derivative, the choroid plexus, failed to be specified or differentiate. Choroid plexus precursors remained proliferative and did not adopt the fate of their lateral telencephalic neighbors. These results demonstrate that BMP signaling is required for the formation of the most dorsal telencephalic derivative, the choroid plexus, and that BMP signaling plays an essential role in locally patterning the dorsal midline. Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates.
AB - BMPs have been proposed to pattern the medial-lateral axis of the telencephalon in a concentration-dependent manner, thus helping to subdivide the embryonic telencephalon into distinct forebrain regions. Using a CRE/loxP genetic approach, we tested this hypothesis by disrupting the Bmpr1a gene in the telencephalon. In mutants, BMP signaling was compromised throughout the dorsal telencephalon, but only the most dorsalmedial derivative, the choroid plexus, failed to be specified or differentiate. Choroid plexus precursors remained proliferative and did not adopt the fate of their lateral telencephalic neighbors. These results demonstrate that BMP signaling is required for the formation of the most dorsal telencephalic derivative, the choroid plexus, and that BMP signaling plays an essential role in locally patterning the dorsal midline. Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates.
UR - http://www.scopus.com/inward/record.url?scp=0037068832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037068832&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(02)00900-5
DO - 10.1016/S0896-6273(02)00900-5
M3 - Article
C2 - 12354394
AN - SCOPUS:0037068832
SN - 0896-6273
VL - 35
SP - 1029
EP - 1041
JO - Neuron
JF - Neuron
IS - 6
ER -