Blood longitudinal (T 1) and transverse (T 2) relaxation time constants at 11.7 Tesla

Ai Ling Lin, Qin Qin, Xia Zhao, Timothy Q. Duong

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Object: The goal of the study was to determine blood T 1 and T 2 values as functions of oxygen saturation (Y), temperature (Temp) and hematocrit (Hct) at an ultrahigh MR field (11.7 T) and explore their impacts on physiological measurements, including cerebral blood flow (CBF), blood volume (CBV) and oxygenation determination. Materials and methods: T 1 and T 2 were simultaneously measured. Temperature was adjusted from 25 to 40°C to determine Temp dependence; Hct of 0.17-0.51 to evaluate Hct dependence at 25 and 37°C; and Y of 40-100% to evaluate Y dependence at 25 and 37°C. Comparisons were made with published data obtained at different magnetic field strengths (B 0). Results: T 1 was positively correlated with Temp, independent of Y, and negatively correlated with Hct. T 2 was negatively correlated with Temp and Hct, but positively correlated with Y, in a non-linear fashion. T 1 increased linearly with B 0, whereas T 2 decreased exponentially with B 0. Conclusion: This study reported blood T 1 and T 2 measurements at 11.7 T for the first time. These blood relaxation data could have implications in numerous functional and physiological MRI studies at 11.7 T.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Issue number3
StatePublished - Jun 2012
Externally publishedYes


  • ASL
  • High fields
  • VASO

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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