TY - JOUR
T1 - Birth Weight and Prematurity in Infants with Single Ventricle Physiology
T2 - Pediatric Heart Network Infant Single Ventricle Trial Screened Population
AU - Williams, Richard V.
AU - Ravishankar, Chitra
AU - Zak, Victor
AU - Evans, Frank
AU - Atz, Andrew M.
AU - Border, William L.
AU - Levine, Jami
AU - Li, Jennifer S.
AU - Mahony, Lynn
AU - Mital, Seema
AU - Pearson, Gail D.
AU - Prakash, Ashwin
AU - Hsu, Daphne T.
PY - 2010/3
Y1 - 2010/3
N2 - Objectives: Although congenital heart disease is associated with low birth weight and prematurity, there is little information about these birth outcomes in infants with single ventricle physiology. We describe the birth outcomes (i.e., gestational age and birth weight) in neonates with single ventricle physiology screened for enrollment in the Pediatric Heart Network's Infant Single Ventricle Trial, compare these outcomes with US norms, and examine the association of birth outcomes with anatomic diagnosis and race. Patients and Methods: All neonates with single ventricle physiology presenting to Infant Single Ventricle Trial centers were screened for enrollment. Demographic data and anatomic diagnoses were obtained from medical records. Results: A total of 1245 neonates with single ventricle physiology were screened at 10 centers (63 to 266 per center). Diagnoses included hypoplastic left heart syndrome in 49%, unbalanced atrioventricular septal defect in 12%, and tricuspid atresia in 9%. Preterm birth occurred in 16% of neonates with single ventricle physiology vs. 12% in normal neonates (P < .001), low birth weight (<2.5 kg) in 18% vs. 8% in normals (P < .001), and small for gestational age (<10th percentile by definition) in 22% vs. 10% in normals (P < .001). A genetic syndrome was reported in 8%. The percentage of preterm birth, low birth weight, and small for gestational age was similar between screened neonates with and without hypoplastic left heart syndrome. Conclusions: In this large, contemporary cohort of neonates with single ventricle physiology, rates of preterm birth, low birth weight, and small for gestational age were higher than in the general population, but similar between screened neonates with and without hypoplastic left heart syndrome.
AB - Objectives: Although congenital heart disease is associated with low birth weight and prematurity, there is little information about these birth outcomes in infants with single ventricle physiology. We describe the birth outcomes (i.e., gestational age and birth weight) in neonates with single ventricle physiology screened for enrollment in the Pediatric Heart Network's Infant Single Ventricle Trial, compare these outcomes with US norms, and examine the association of birth outcomes with anatomic diagnosis and race. Patients and Methods: All neonates with single ventricle physiology presenting to Infant Single Ventricle Trial centers were screened for enrollment. Demographic data and anatomic diagnoses were obtained from medical records. Results: A total of 1245 neonates with single ventricle physiology were screened at 10 centers (63 to 266 per center). Diagnoses included hypoplastic left heart syndrome in 49%, unbalanced atrioventricular septal defect in 12%, and tricuspid atresia in 9%. Preterm birth occurred in 16% of neonates with single ventricle physiology vs. 12% in normal neonates (P < .001), low birth weight (<2.5 kg) in 18% vs. 8% in normals (P < .001), and small for gestational age (<10th percentile by definition) in 22% vs. 10% in normals (P < .001). A genetic syndrome was reported in 8%. The percentage of preterm birth, low birth weight, and small for gestational age was similar between screened neonates with and without hypoplastic left heart syndrome. Conclusions: In this large, contemporary cohort of neonates with single ventricle physiology, rates of preterm birth, low birth weight, and small for gestational age were higher than in the general population, but similar between screened neonates with and without hypoplastic left heart syndrome.
KW - Low Birth Weight
KW - Preterm Birth
KW - Single Ventricle Physiology
KW - Small for Gestational Age
UR - http://www.scopus.com/inward/record.url?scp=77954354159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954354159&partnerID=8YFLogxK
U2 - 10.1111/j.1747-0803.2009.00369.x
DO - 10.1111/j.1747-0803.2009.00369.x
M3 - Article
C2 - 20412481
AN - SCOPUS:77954354159
SN - 1747-079X
VL - 5
SP - 96
EP - 103
JO - Congenital Heart Disease
JF - Congenital Heart Disease
IS - 2
ER -