TY - JOUR
T1 - Biomarkers of aging for the identification and evaluation of longevity interventions
AU - Biomarkers of Aging Consortium
AU - Moqri, Mahdi
AU - Herzog, Chiara
AU - Poganik, Jesse R.
AU - Justice, Jamie
AU - Belsky, Daniel W.
AU - Higgins-Chen, Albert
AU - Moskalev, Alexey
AU - Fuellen, Georg
AU - Cohen, Alan A.
AU - Bautmans, Ivan
AU - Widschwendter, Martin
AU - Ding, Jingzhong
AU - Fleming, Alexander
AU - Mannick, Joan
AU - Han, Jing Dong Jackie
AU - Zhavoronkov, Alex
AU - Barzilai, Nir
AU - Kaeberlein, Matt
AU - Cummings, Steven
AU - Kennedy, Brian K.
AU - Ferrucci, Luigi
AU - Horvath, Steve
AU - Verdin, Eric
AU - Maier, Andrea B.
AU - Snyder, Michael P.
AU - Sebastiano, Vittorio
AU - Gladyshev, Vadim N.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/8/31
Y1 - 2023/8/31
N2 - With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
AB - With the rapid expansion of aging biology research, the identification and evaluation of longevity interventions in humans have become key goals of this field. Biomarkers of aging are critically important tools in achieving these objectives over realistic time frames. However, the current lack of standards and consensus on the properties of a reliable aging biomarker hinders their further development and validation for clinical applications. Here, we advance a framework for the terminology and characterization of biomarkers of aging, including classification and potential clinical use cases. We discuss validation steps and highlight ongoing challenges as potential areas in need of future research. This framework sets the stage for the development of valid biomarkers of aging and their ultimate utilization in clinical trials and practice.
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U2 - 10.1016/j.cell.2023.08.003
DO - 10.1016/j.cell.2023.08.003
M3 - Review article
C2 - 37657418
AN - SCOPUS:85169521965
SN - 0092-8674
VL - 186
SP - 3758
EP - 3775
JO - Cell
JF - Cell
IS - 18
ER -