Biology and therapeutic advances for pediatric osteosarcoma

Neyssa Marina, Mark Gebhardt, Lisa Teot, Richard Gorlick

Research output: Contribution to journalReview articlepeer-review

609 Scopus citations


Osteosarcoma is the most common malignant bone tumor in children and adolescents. Survival for these patients was poor with the use of surgery and/or radiotherapy. The introduction of multi-agent chemotherapy dramatically improved the outcome for these patients and the majority of modern series report 3-year disease-free survival of 60%-70%. This paper describes current strategies for treating patients with osteosarcoma as well as review of the clinical features, radiologic and diagnostic work-up, and pathology. The authors review the state of the art management for patients with osteosarcoma in North America and Europe including the use of limb-salvage procedures and reconstruction as well as discuss the etiologic and biologic factors associated with tumor development. Therapy-related sequelae and future directions in the biology and therapy for these patients are also discussed.

Original languageEnglish (US)
Pages (from-to)422-441
Number of pages20
Issue number4
StatePublished - 2004
Externally publishedYes


  • Biology
  • Multidisciplinary treatment
  • Pediatric osteosarcoma
  • Therapeutic advances
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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