Abstract
Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
Original language | English (US) |
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Pages (from-to) | 813-820 |
Number of pages | 8 |
Journal | Nature |
Volume | 414 |
Issue number | 6865 |
DOIs | |
State | Published - Dec 13 2001 |
ASJC Scopus subject areas
- General