BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia

Elyse A. Olesinski; Karanpreet S. Bhatia; Aarthi N. Mahesh; Shazwina Rosli; Jameelah S. Mohamed; Wei Y. Jen; Nitin Jain; Jacqueline S. Garcia; Gee C. Wong; Melissa Ooi; Anthony Letai; Marina Konopleva; Shruti Bhatt

doi:10.1182/bloodadvances.2022007728

BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia

Elyse A. Olesinski, Karanpreet S. Bhatia, Aarthi N. Mahesh, Shazwina Rosli, Jameelah S. Mohamed, Wei Y. Jen, Nitin Jain, Jacqueline S. Garcia, Gee C. Wong, Melissa Ooi, Anthony Letai, Marina Konopleva, Shruti Bhatt

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Original language	English (US)
Pages (from-to)	2917-2923
Number of pages	7
Journal	Blood Advances
Volume	7
Issue number	12
DOIs	https://doi.org/10.1182/bloodadvances.2022007728
State	Published - Jun 1 2023
Externally published	Yes

ASJC Scopus subject areas

Hematology

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10.1182/bloodadvances.2022007728

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Olesinski, E. A., Bhatia, K. S., Mahesh, A. N., Rosli, S., Mohamed, J. S., Jen, W. Y., Jain, N., Garcia, J. S., Wong, G. C., Ooi, M., Letai, A., Konopleva, M., & Bhatt, S. (2023). BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia. Blood Advances, 7(12), 2917-2923. https://doi.org/10.1182/bloodadvances.2022007728

@article{7b996d341f6f40acb0640aa7e9591b6a,

title = "BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia",

author = "Olesinski, {Elyse A.} and Bhatia, {Karanpreet S.} and Mahesh, {Aarthi N.} and Shazwina Rosli and Mohamed, {Jameelah S.} and Jen, {Wei Y.} and Nitin Jain and Garcia, {Jacqueline S.} and Wong, {Gee C.} and Melissa Ooi and Anthony Letai and Marina Konopleva and Shruti Bhatt",

note = "Funding Information: The authors thank all patients and families who consented to providing samples for this study at the Dana-Farber Cancer Institute, MD Anderson Cancer Center, National University Hospital Singapore, and Singapore General Hospital. The authors thank Triona Ni Chonghaile, Royal College of Surgeons in Ireland, for providing the editorial assistance. S.B. is a recipient of the Leukemia and Lymphoma Society Career Development Fellow Award. S.B. acknowledges support from the American Society of Hematology Global Research Award, NCIS and NUS Cancer Program Seed funding grant, and the National Medical Research Council of Singapore under award number OFIRG21NOV-0062. M.K. was supported by R01CA241191. J.S.G. was supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) under award number K08CA245209, NIH/NCI SPORE in Myeloid Malignancies Grant Number 1P50CA206963, and the Ted and Eileen Pasquarello Tissue Bank in Hematologic Malignancies. A.L. acknowledges Funding Information: Acknowledgments: The authors thank all patients and families who consented to providing samples for this study at the Dana-Farber Cancer Institute, MD Anderson Cancer Center, National University Hospital Singapore, and Singapore General Hospital. The authors thank Triona Ni Chonghaile, Royal College of Surgeons in Ireland, for providing the editorial assistance. S.B. is a recipient of the Leukemia and Lymphoma Society Career Development Fellow Award. S.B. acknowledges support from the American Society of Hematology Global Research Award, NCIS and NUS Cancer Program Seed funding grant, and the National Medical Research Council of Singapore under award number OFIRG21NOV-0062. M.K. was supported by R01CA241191. J.S.G. was supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) under award number K08CA245209, NIH/NCI SPORE in Myeloid Malignancies Grant Number 1P50CA206963, and the Ted and Eileen Pasquarello Tissue Bank in Hematologic Malignancies. A.L. acknowledges Funding Information: support from the NIH under award number P01CA066996. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or NCI.",

year = "2023",

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doi = "10.1182/bloodadvances.2022007728",

language = "English (US)",

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publisher = "American Society of Hematology",

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T1 - BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia

AU - Olesinski, Elyse A.

AU - Bhatia, Karanpreet S.

AU - Mahesh, Aarthi N.

AU - Rosli, Shazwina

AU - Mohamed, Jameelah S.

AU - Jen, Wei Y.

AU - Jain, Nitin

AU - Garcia, Jacqueline S.

AU - Wong, Gee C.

AU - Ooi, Melissa

AU - Letai, Anthony

AU - Konopleva, Marina

AU - Bhatt, Shruti

N1 - Funding Information: The authors thank all patients and families who consented to providing samples for this study at the Dana-Farber Cancer Institute, MD Anderson Cancer Center, National University Hospital Singapore, and Singapore General Hospital. The authors thank Triona Ni Chonghaile, Royal College of Surgeons in Ireland, for providing the editorial assistance. S.B. is a recipient of the Leukemia and Lymphoma Society Career Development Fellow Award. S.B. acknowledges support from the American Society of Hematology Global Research Award, NCIS and NUS Cancer Program Seed funding grant, and the National Medical Research Council of Singapore under award number OFIRG21NOV-0062. M.K. was supported by R01CA241191. J.S.G. was supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) under award number K08CA245209, NIH/NCI SPORE in Myeloid Malignancies Grant Number 1P50CA206963, and the Ted and Eileen Pasquarello Tissue Bank in Hematologic Malignancies. A.L. acknowledges Funding Information: Acknowledgments: The authors thank all patients and families who consented to providing samples for this study at the Dana-Farber Cancer Institute, MD Anderson Cancer Center, National University Hospital Singapore, and Singapore General Hospital. The authors thank Triona Ni Chonghaile, Royal College of Surgeons in Ireland, for providing the editorial assistance. S.B. is a recipient of the Leukemia and Lymphoma Society Career Development Fellow Award. S.B. acknowledges support from the American Society of Hematology Global Research Award, NCIS and NUS Cancer Program Seed funding grant, and the National Medical Research Council of Singapore under award number OFIRG21NOV-0062. M.K. was supported by R01CA241191. J.S.G. was supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) under award number K08CA245209, NIH/NCI SPORE in Myeloid Malignancies Grant Number 1P50CA206963, and the Ted and Eileen Pasquarello Tissue Bank in Hematologic Malignancies. A.L. acknowledges Funding Information: support from the NIH under award number P01CA066996. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or NCI.

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BH3 profiling identifies BCL-2 dependence in adult patients with early T-cell progenitor acute lymphoblastic leukemia

ASJC Scopus subject areas

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