Abstract
Serum concentrations of beta-2-microglobulin (B2-M) were correlated with disease outcome in 40 children infected by the human immunodeficiency virus. Serum B2-M serum concentrations below 3.0 mg/100 ml or decreasing concentrations were indicative of a stable disease course but were also noted preterminally in lymphopenic children. Of 20 patients with B2-M concentrations above 3.0 mg/liter, 12 had a progressive disease course and 8 remained stable. In the latter 8 patients the B2-M values decreased with time. Elevated B2-M concentrations were also noted in infants younger than 1 year of age and denoted active human immunodeficiency virus infection. B2-M serum concentrations are a useful prognostic marker in human immunodeficiency virus-infected children.
Original language | English (US) |
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Pages (from-to) | 807-809 |
Number of pages | 3 |
Journal | Pediatric Infectious Disease Journal |
Volume | 9 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1990 |
Keywords
- Acquired immunodeficiency syndrome
- Beta-2-microglobulin
- Early markers
- Human immunodeficiency virus infection
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Microbiology (medical)
- Infectious Diseases