Best Practices for Minimally Invasive Lumbar Spinal Stenosis Treatment 2.0 (MIST): Consensus Guidance from the American Society of Pain and Neuroscience (ASPN)

Timothy R. Deer, Jay S. Grider, Jason E. Pope, Tim J. Lamer, Sayed E. Wahezi, Jonathan M. Hagedorn, Steven Falowski, Reda Tolba, Jay M. Shah, Natalie Strand, Alex Escobar, Mark Malinowski, Anjum Bux, Navdeep Jassal, Jennifer Hah, Jacqueline Weisbein, Nestor D. Tomycz, Jessica Jameson, Erika A. Petersen, Dawood Sayed

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Introduction: Lumbar spinal stenosis (LSS) is a common spinal disease of aging with a growing patient population, paralleling population growth. Minimally invasive treatments are evolving, and the use of these techniques needs guidance to provide the optimal patient safety and efficacy outcomes. Methods: The American Society of Pain and Neuroscience (ASPN) identified an educational need for guidance on the prudent use of the innovative minimally invasive surgical therapies for the treatment of symptomatic LSS. The executive board nominated experts spanning anesthesiology, physiatry, orthopedic surgery, and neurosurgery based on expertise, publications, research, diversity and field of practice. Evidence was reviewed, graded using the United States Preventive Services Task Force (USPSTF) criteria for evidence and recommendation strength and grade, and expert opinion was added to make consensus points for best practice. Results: The world literature in English was searched using Medline, EMBASE, Cochrane CENTRAL, BioMed Central, Web of Science, Google Scholar, PubMed, Current Contents Connect, Scopus, and meeting abstracts to identify and compile the evidence (per section) for LSS-related pain. Search words were selected based upon the section represented. Identified peer-reviewed literature was critiqued using USPSTF criteria and consensus points are presented. Discussion: The algorithm for patient selection in the management of symptomatic spinal stenosis is evolving. Careful consideration of patient selection and anatomic architecture variance is critical for improved outcomes and patient safety. Conclusion: ASPN created a guidance for best practice for minimally invasive surgical treatment of symptomatic spinal stenosis.

Original languageEnglish (US)
Pages (from-to)1325-1354
Number of pages30
JournalJournal of Pain Research
StatePublished - 2022
Externally publishedYes


  • epidural steroid injections
  • interspinous spacers
  • intrathecal drug delivery
  • neurostimulation
  • open decompression
  • percutaneous image-guided lumbar decompression

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Best Practices for Minimally Invasive Lumbar Spinal Stenosis Treatment 2.0 (MIST): Consensus Guidance from the American Society of Pain and Neuroscience (ASPN)'. Together they form a unique fingerprint.

Cite this