Behavioral indications for serotonin receptor hypersensitivity in panic disorder

RenéS S. Kahn; Scott Wetzler; Herman M. van Praag; Gregory M. Asnis; Tim Strauman

doi:10.1016/0165-1781(88)90163-1

Behavioral indications for serotonin receptor hypersensitivity in panic disorder

RenéS S. Kahn, Scott Wetzler, Herman M. van Praag, Gregory M. Asnis, Tim Strauman

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

Original language	English (US)
Pages (from-to)	101-104
Number of pages	4
Journal	Psychiatry Research
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(88)90163-1
State	Published - Jul 1988

Keywords

Serotonin
anxiety
m-chlorophenylpiperazine
panic disorder
receptor

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(88)90163-1

Cite this

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title = "Behavioral indications for serotonin receptor hypersensitivity in panic disorder",

abstract = "Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.",

keywords = "Serotonin, anxiety, m-chlorophenylpiperazine, panic disorder, receptor",

author = "Kahn, {Ren{\'e}S S.} and Scott Wetzler and {van Praag}, {Herman M.} and Asnis, {Gregory M.} and Tim Strauman",

note = "Funding Information: Acknowledgment. This work has been supported by the Dorothy and Marty Silverman Chair in Psychiatry and the Ruane Foundation.",

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AU - Kahn, RenéS S.

AU - Wetzler, Scott

AU - van Praag, Herman M.

AU - Asnis, Gregory M.

AU - Strauman, Tim

N1 - Funding Information: Acknowledgment. This work has been supported by the Dorothy and Marty Silverman Chair in Psychiatry and the Ruane Foundation.

PY - 1988/7

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N2 - Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

AB - Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

KW - Serotonin

KW - anxiety

KW - m-chlorophenylpiperazine

KW - panic disorder

KW - receptor

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Behavioral indications for serotonin receptor hypersensitivity in panic disorder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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