Baclofen inhibits amygdala kindling in immature rats

John N.D. Wurpel; Ellen F. Sperber; Solomon L. Moshé

doi:10.1016/0920-1211(90)90060-9

Baclofen inhibits amygdala kindling in immature rats

John N.D. Wurpel, Ellen F. Sperber, Solomon L. Moshé

Neurology

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20 Scopus citations

Abstract

The possible effectiveness of systemic infusions of baclofen (a GABA_B receptor agonist) in the modification of seizures in developing animals has not yet been established. In this report, we studied the effects of systemic baclofen infusions on amygdala kindling in 16-day-old rat pups. Baclofen suppressed the development of kindling without altering the local afterdischarge threshold. Moreover, baclofen suppressed the severity and duration of established kindled seizures and increased the intensity of postictal refractoriness. The data suggest that baclofen may be a useful antiepileptic agent in this age group.

Original language	English (US)
Pages (from-to)	1-7
Number of pages	7
Journal	Epilepsy Research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/0920-1211(90)90060-9
State	Published - 1990

Keywords

(Rat)
Amgydala
Baclofen
GABA
Kindling
Newborn
Seizures

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/0920-1211(90)90060-9

Cite this

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title = "Baclofen inhibits amygdala kindling in immature rats",

abstract = "The possible effectiveness of systemic infusions of baclofen (a GABAB receptor agonist) in the modification of seizures in developing animals has not yet been established. In this report, we studied the effects of systemic baclofen infusions on amygdala kindling in 16-day-old rat pups. Baclofen suppressed the development of kindling without altering the local afterdischarge threshold. Moreover, baclofen suppressed the severity and duration of established kindled seizures and increased the intensity of postictal refractoriness. The data suggest that baclofen may be a useful antiepileptic agent in this age group.",

keywords = "(Rat), Amgydala, Baclofen, GABA, Kindling, Newborn, Seizures",

author = "Wurpel, {John N.D.} and Sperber, {Ellen F.} and Mosh{\'e}, {Solomon L.}",

note = "Funding Information: Supported by Grants NS 20253 and R-36986 from the United Cerebral Palsy Associations.",

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AU - Sperber, Ellen F.

AU - Moshé, Solomon L.

N1 - Funding Information: Supported by Grants NS 20253 and R-36986 from the United Cerebral Palsy Associations.

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AB - The possible effectiveness of systemic infusions of baclofen (a GABAB receptor agonist) in the modification of seizures in developing animals has not yet been established. In this report, we studied the effects of systemic baclofen infusions on amygdala kindling in 16-day-old rat pups. Baclofen suppressed the development of kindling without altering the local afterdischarge threshold. Moreover, baclofen suppressed the severity and duration of established kindled seizures and increased the intensity of postictal refractoriness. The data suggest that baclofen may be a useful antiepileptic agent in this age group.

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KW - Newborn

KW - Seizures

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Baclofen inhibits amygdala kindling in immature rats

Abstract

Keywords

ASJC Scopus subject areas

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