Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

Matthieu P.M.H. Benoit; Michael J. Plevin

doi:10.1007/s12104-012-9416-8

Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

Matthieu P.M.H. Benoit, Michael J. Plevin

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.

Original language	English (US)
Pages (from-to)	229-233
Number of pages	5
Journal	Biomolecular NMR Assignments
Volume	7
Issue number	2
DOIs	https://doi.org/10.1007/s12104-012-9416-8
State	Published - Oct 2013
Externally published	Yes

Keywords

Double-stranded RNA binding domain
Micro-RNA
TRBP
Triple resonance NMR experiments

ASJC Scopus subject areas

Structural Biology
Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12104-012-9416-8

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title = "Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP",

abstract = "TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.",

keywords = "Double-stranded RNA binding domain, Micro-RNA, TRBP, Triple resonance NMR experiments",

author = "Benoit, {Matthieu P.M.H.} and Plevin, {Michael J.}",

note = "Funding Information: Acknowledgments The authors would like to thank Drs. A. Favier and E. Condamine for assistance with NMR data acquistion, Drs. B. Bersch and J. Boisbouvier for helpful commments, and the Partnership for Structural Biology, Grenoble, for access to integrated structural biology platforms. This work was supported in part by funding from the E. U. (FP7-PEOPLE-IRG-2008) and l{\textquoteright}Agence pour la Recherche sur le Cancer to MJP. MPMHB acknowledges the CEA for a Ph. D. studentship.",

year = "2013",

month = oct,

doi = "10.1007/s12104-012-9416-8",

language = "English (US)",

volume = "7",

pages = "229--233",

journal = "Biomolecular NMR Assignments",

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T1 - Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

AU - Benoit, Matthieu P.M.H.

AU - Plevin, Michael J.

N1 - Funding Information: Acknowledgments The authors would like to thank Drs. A. Favier and E. Condamine for assistance with NMR data acquistion, Drs. B. Bersch and J. Boisbouvier for helpful commments, and the Partnership for Structural Biology, Grenoble, for access to integrated structural biology platforms. This work was supported in part by funding from the E. U. (FP7-PEOPLE-IRG-2008) and l’Agence pour la Recherche sur le Cancer to MJP. MPMHB acknowledges the CEA for a Ph. D. studentship.

PY - 2013/10

Y1 - 2013/10

N2 - TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.

AB - TAR-RNA binding protein (TRBP) is a multidomain human protein involved in micro-RNA (miRNA) biogenesis. TRBP is a component of both the Dicer complex, which processes precursor miRNAs, and the RNA-induced silencing complex-loading complex. In addition, TRBP is implicated in the human immunodeficiency virus replication cycle and interferon-protein kinase R activity. TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2.

KW - Double-stranded RNA binding domain

KW - Micro-RNA

KW - TRBP

KW - Triple resonance NMR experiments

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SN - 1874-2718

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EP - 233

JO - Biomolecular NMR Assignments

JF - Biomolecular NMR Assignments

IS - 2

ER -

Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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