Azidothymidine(AZT)‐induced siderosis

Simeon Pollack; Janet Weaver

doi:10.1002/ajh.2830430314

Azidothymidine(AZT)‐induced siderosis

Simeon Pollack, Janet Weaver

Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Azidothymidine(AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT‐treated mice.

Original language	English (US)
Pages (from-to)	230-233
Number of pages	4
Journal	American Journal of Hematology
Volume	43
Issue number	3
DOIs	https://doi.org/10.1002/ajh.2830430314
State	Published - Jul 1993

Keywords

AIDS
iron
liver
macrophage

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajh.2830430314

Cite this

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title = "Azidothymidine(AZT)‐induced siderosis",

abstract = "Azidothymidine(AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT‐treated mice.",

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author = "Simeon Pollack and Janet Weaver",

year = "1993",

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AU - Pollack, Simeon

AU - Weaver, Janet

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N2 - Azidothymidine(AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT‐treated mice.

AB - Azidothymidine(AZT) interferes with heme synthesis. This should upregulate the synthesis of transferrin receptors and increase the amount of iron taken up by the cell. We found a 50% increase in the iron content of liver and a 20% increase in the iron content of macrophages in AZT‐treated mice.

KW - AIDS

KW - iron

KW - liver

KW - macrophage

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DO - 10.1002/ajh.2830430314

M3 - Article

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AN - SCOPUS:0027273553

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IS - 3

ER -

Azidothymidine(AZT)‐induced siderosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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