Autophagy in T Cell Function and Aging

Fernando Macian

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


Dysregulation of autophagy with age has been identified as a central mechanism of aging affecting many cells and tissues. T cells do also show decreased activity with age of different autophagic pathways. Here, we will review the current knowledge of the different functions that autophagy has in the regulation of T cell homeostasis, differentiation and function and explore how the age-associated decreased in autophagy activity may contribute to the altered T cell responses that characterize T cell immunosenescence.

Original languageEnglish (US)
Article number213
JournalFrontiers in Cell and Developmental Biology
StatePublished - Oct 2 2019


  • T cell
  • aging
  • autophagy
  • chaperone-mediated autophagy
  • immunosenescence

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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