Autophagy in neurons: it is not all about food

Research output: Contribution to journalShort surveypeer-review

38 Scopus citations


The primary function of autophagy in most cell types is adaptation to starvation. Because neurons are protected from this type of stress, the physiological role of autophagy in normal functioning neurons was, until now, poorly understood. Using genetic manipulations to block autophagy in neurons selectively, Mizushima's and Tanaka's groups have recently presented conclusive evidence for an essential role of constitutive autophagy in neuronal survival. These studies provide new insights into the relationship between autophagy malfunctioning and neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalTrends in Molecular Medicine
Issue number10
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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