Autophagy and aging: the importance of maintaining "clean" cells.

Ana Maria Cuervo, Ettore Bergamini, Ulf T. Brunk, Wulf Dröge, Martine Ffrench, Alexei Terman

Research output: Contribution to journalReview articlepeer-review

683 Scopus citations


A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related manifestations. In this work we review the molecular defects responsible for the malfunctioning of two forms of autophagy, macroautophagy and chaperone-mediated autophagy, in old mammals, and highlight general and cell-type specific consequences of dysfunction of the autophagic system with age. Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents. These and other possible experimental restorative efforts are discussed.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
Issue number3
StatePublished - 2005

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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