Abstract
The prognosis for patients with central nervous system (CNS) involvement by recurrent or refractory diffuse large B-cell lymphoma is poor, with overall survival (OS) of 4-10 months. High-dose chemotherapy (HDC) and autologous stem cell transplant (ASCT) is a potential treatment alternative. We reviewed patients with recurrent primary (PCNSL) or secondary (SCNSL) CNS lymphoma referred for consolidation HDC-ASCT utilizing thiotepa, busulfan and cyclophosphamide (TBC). Among the 17 patients included, all had achieved a complete remission after salvage induction chemotherapy, which incorporated methotrexate in 82% of patients. Two patients failed stem-cell harvesting and 15 (88%) underwent transplant. The estimated 3-year progression-free survival (PFS) and OS were both 93% (95% confidence interval 61-99%). Median PFS and OS were not reached. There was no transplant-related mortality. These results confirm the benefit of TBC followed by ASCT in select patients with recurrent PCNSL and suggest a potential role for the regimen in those with SCNSL. Further investigation is warranted.
Original language | English (US) |
---|---|
Pages (from-to) | 361-367 |
Number of pages | 7 |
Journal | Leukemia and Lymphoma |
Volume | 56 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2015 |
Externally published | Yes |
Keywords
- Autologous stem cell transplant
- Central nervous system lymphoma
- Chemotherapeutic approaches
- High-dose chemotherapy
- Stem cell mobilization
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research