TY - JOUR
T1 - Atypical Psychosis With Disseminated Subpial Demyelination
AU - Neumann, Paul E.
AU - Mehler, Mark F.
AU - Horoupian, Dikran S.
AU - Merriam, Arnold E.
PY - 1988/6
Y1 - 1988/6
N2 - A 34-year-old woman experienced three episodes of an atypical psychosis, characterized by confusion, agitation, delusional thinking, paranoid ideation, and auditory hallucinations, during the 14 months prior to her death. Findings of gross examination of the brain and spinal cord were unremarkable. Histologic examination revealed scattered subpial foci of demyelination throughout the brain stem, with involvement of the hippocampal formation bilaterally. Although occasional active lesions at early stages of development were noted, most lesions were gliotic and therefore quiescent. This case and one similar example of disseminated subpial demyelination found in the literature probably represent an unusual variant of multiple sclerosis.
AB - A 34-year-old woman experienced three episodes of an atypical psychosis, characterized by confusion, agitation, delusional thinking, paranoid ideation, and auditory hallucinations, during the 14 months prior to her death. Findings of gross examination of the brain and spinal cord were unremarkable. Histologic examination revealed scattered subpial foci of demyelination throughout the brain stem, with involvement of the hippocampal formation bilaterally. Although occasional active lesions at early stages of development were noted, most lesions were gliotic and therefore quiescent. This case and one similar example of disseminated subpial demyelination found in the literature probably represent an unusual variant of multiple sclerosis.
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U2 - 10.1001/archneur.1988.00520300052018
DO - 10.1001/archneur.1988.00520300052018
M3 - Article
C2 - 3369970
AN - SCOPUS:0023917861
SN - 0003-9942
VL - 45
SP - 634
EP - 636
JO - Archives of Neurology
JF - Archives of Neurology
IS - 6
ER -