Abstract
Atrial fibrillation (AF) is the most common sustained arrhythmia, especially in the elderly, and has a significant genetic component. Recently, several independent investigators have demonstrated a functional role for small non-coding RNAs (microRNAs) in the pathophysiology of this cardiac arrhythmia. This report represents a systematic and updated appraisal of the main studies that established a mechanistic association between specific microRNAs and AF, focusing both on the regulation of electrical and structural remodeling of cardiac tissue.
Original language | English (US) |
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Article number | 00015 |
Journal | Frontiers in Physiology |
Volume | 5 JAN |
DOIs | |
State | Published - 2014 |
Externally published | Yes |
Keywords
- Apoptosis
- Atrial fibrillation
- Electrical remodeling
- Electrophysiology
- Fibrosis
- MicroRNA (miRNA)
- Structural remodeling
ASJC Scopus subject areas
- Physiology
- Physiology (medical)