Atrial fibrillation and cardiac resynchronization therapy: The MASCOT study

Luigi Padeletti, Nicola Musilli, Maria Cristina Porciani, Andrea Colella, Luigi Di Biase, Giuseppe Ricciardi, Paolo Pieragnoli, Antonio Michelucci, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Atrial fibrillation (AF) and congestive heart failure (CHF) share several characteristics and often coexist in the same patient. Both are responsible for significant morbidity and mortality, are increasing in prevalence, and are major sources of health expenditure. The Management of Atrial fibrillation Suppression in AF-HF COmorbidity Therapy (MASCOT) study is a European, single-blind, prospective, controlled, multicentre, randomized clinical trial designed to examine whether adding the AF Suppression™ Algorithm to cardiac resynchronization therapy (CRT) improves the prognosis of patients with CHF. The patients will be randomly assigned to a CRT-only group, with the AF Suppression™ algorithm programmed OFF (control group), versus a CRT + AF Suppression™ group, with the algorithm programmed ON (treatment group). The primary study endpoint is development of permanent AF, and secondary endpoints are safety of the AF Suppression™ algorithm, and evolution of multiple clinical variables over 24 months of follow-up. CRT combined with a refined atrial tachyarrhythmia prevention pacing algorithm may represent a major advance in the management of AF and CHF by electrical stimulation.

Original languageEnglish (US)
Pages (from-to)S49-S54
Issue numberSUPPL. 1
StatePublished - Sep 2004
Externally publishedYes


  • Atrial fibrillation
  • Atrial pacing
  • Cardiac resynchronization therapy
  • Overdrive pacing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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