TY - JOUR
T1 - Atherosclerosis in Survivors of Kawasaki Disease
AU - Gupta-Malhotra, Monesha
AU - Gruber, Dorota
AU - Abraham, Seena S.
AU - Roman, Mary J.
AU - Zabriskie, John B.
AU - Hudgins, Lisa C.
AU - Flynn, Patrick A.
AU - Levine, Daniel M.
AU - Okorie, Uzoma
AU - Baday, Aline
AU - Schiller, Myles S.
AU - Maturi, Janet
AU - Meehan, Diane
AU - Dyme, Joshua
AU - Parker, Thomas S.
AU - Wittkowski, Knut M.
AU - Gersony, Welton M.
AU - Cooper, Rubin S.
PY - 2009/10
Y1 - 2009/10
N2 - Objectives: To test the hypothesis that long-term survivors of low-risk Kawasaki disease (KD) have ongoing vascular inflammation and dysfunction and a higher risk of accelerated atherosclerosis than healthy control subjects. Study design: Twenty-eight patients with KD (7-20 years after acute illness) and 27 age-matched healthy control subjects were examined for medical and dietary history, serum markers of atherosclerotic risk and inflammation, carotid intimal-medial thickness (CIMT) with vascular ultrasound scanning and arterial stiffness with applanation tonometry. Results: Patients and control subjects were similar in age, sex, body mass index, waist-to-hip ratio, blood pressure, cigarette smoking, family history, diet, high-density lipoprotein cholesterol level, lipoprotein (a) level, homocysteine level, glucose level, insulin level, CIMT, arterial stiffness, C-reactive protein level, and inflammatory cytokine level. Levels of total cholesterol and apolipoprotein B were significantly higher in patients with KD than in control subjects. Conclusions: There was no evidence of increased atherosclerosis. Small but significant differences in cholesterol and apolipoprotein B levels could suggest increased future risk for atherosclerosis and warrant further study.
AB - Objectives: To test the hypothesis that long-term survivors of low-risk Kawasaki disease (KD) have ongoing vascular inflammation and dysfunction and a higher risk of accelerated atherosclerosis than healthy control subjects. Study design: Twenty-eight patients with KD (7-20 years after acute illness) and 27 age-matched healthy control subjects were examined for medical and dietary history, serum markers of atherosclerotic risk and inflammation, carotid intimal-medial thickness (CIMT) with vascular ultrasound scanning and arterial stiffness with applanation tonometry. Results: Patients and control subjects were similar in age, sex, body mass index, waist-to-hip ratio, blood pressure, cigarette smoking, family history, diet, high-density lipoprotein cholesterol level, lipoprotein (a) level, homocysteine level, glucose level, insulin level, CIMT, arterial stiffness, C-reactive protein level, and inflammatory cytokine level. Levels of total cholesterol and apolipoprotein B were significantly higher in patients with KD than in control subjects. Conclusions: There was no evidence of increased atherosclerosis. Small but significant differences in cholesterol and apolipoprotein B levels could suggest increased future risk for atherosclerosis and warrant further study.
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U2 - 10.1016/j.jpeds.2009.04.054
DO - 10.1016/j.jpeds.2009.04.054
M3 - Article
C2 - 19595365
AN - SCOPUS:70349164457
SN - 0022-3476
VL - 155
SP - 572
EP - 577
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -