(At Least) Once in Her Lifetime: Global Cervical Cancer Prevention

Philip E. Castle, Amanda Pierz

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Cervical cancer disproportionately burdens lower-resourced settings, in which nearly 90% of cervical cancer and cervical cancer–related deaths occur. Targeting human papillomavirus (HPV) by prophylactic HPV vaccination in young adolescent girls and HPV-based screening in mid-adult women offers the most cost-effective strategy to reduce cervical cancer burden worldwide and mitigate the health disparities in cervical cancer burden between low-resourced and high-resourced settings. Political and social will, along with the necessary financial investments, will be necessary to realize the opportunity for significant global reductions in the cervical cancer burden. Perfect cervical cancer prevention (total eradication) is practically and financially unrealistic.

Original languageEnglish (US)
Pages (from-to)107-123
Number of pages17
JournalObstetrics and Gynecology Clinics of North America
Issue number1
StatePublished - Mar 2019


  • Cervical cancer
  • Cervical intraepithelial neoplasia (CIN)
  • Cytology
  • Global health
  • Human papillomavirus (HPV)
  • Pap
  • Screening
  • Vaccination

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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