Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Summer V. Harvey; Nicolas Wentzensen; Kimberly Bertrand; Amanda Black; Louise A. Brinton; Chu Chen; Laura Costas; Luigino Dal Maso; Immaculata De Vivo; Mengmeng Du; Montserrat Garcia-Closas; Marc T. Goodman; Jessica Gorzelitz; Lisa Johnson; James V. Lacey; Linda Liao; Loren Lipworth; Jolanta Lissowska; Anthony B. Miller; Kelli O’Connell; Tracy A. O’Mara; Xiao Ou; Julie R. Palmer; Alpa V. Patel; Sonia Paytubi; Beatriz Pelegrina; Stacey Petruzella; Anna Prizment; Thomas Rohan; Sven Sandin; Veronica Wendy Setiawan; Rashmi Sinha; Britton Trabert; Penelope M. Webb; Lynne R. Wilkens; Wanghong Xu; Hannah P. Yang; Wei Zheng; Megan A. Clarke

doi:10.1093/ije/dyad046

Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Summer V. Harvey, Nicolas Wentzensen, Kimberly Bertrand, Amanda Black, Louise A. Brinton, Chu Chen, Laura Costas, Luigino Dal Maso, Immaculata De Vivo, Mengmeng Du, Montserrat Garcia-Closas, Marc T. Goodman, Jessica Gorzelitz, Lisa Johnson, James V. Lacey, Linda Liao, Loren Lipworth, Jolanta Lissowska, Anthony B. Miller, Kelli O’ConnellTracy A. O’Mara, Xiao Ou, Julie R. Palmer, Alpa V. Patel, Sonia Paytubi, Beatriz Pelegrina, Stacey Petruzella, Anna Prizment, Thomas Rohan, Sven Sandin, Veronica Wendy Setiawan, Rashmi Sinha, Britton Trabert, Penelope M. Webb, Lynne R. Wilkens, Wanghong Xu, Hannah P. Yang, Wei Zheng, Megan A. Clarke

Epidemiology & Population Health

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18–21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). Methods: We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m²) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. Results: We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR ¼ 2.85, 95% CI ¼ 2.47–3.29) and young adulthood (OR ¼ 1.26, 95% CI ¼ 1.06–1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Conclusions: Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

Original language	English (US)
Pages (from-to)	1086-1099
Number of pages	14
Journal	International journal of epidemiology
Volume	52
Issue number	4
DOIs	https://doi.org/10.1093/ije/dyad046
State	Published - Aug 1 2023

Keywords

BMI
BMI change
Endometrial cancer
epidemiology
gynaecology
life course exposures
obesity
uterine cancer
weight change
weight loss

ASJC Scopus subject areas

Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ije/dyad046

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Harvey, S. V., Wentzensen, N., Bertrand, K., Black, A., Brinton, L. A., Chen, C., Costas, L., Maso, L. D., De Vivo, I., Du, M., Garcia-Closas, M., Goodman, M. T., Gorzelitz, J., Johnson, L., Lacey, J. V., Liao, L., Lipworth, L., Lissowska, J., Miller, A. B., ... Clarke, M. A. (2023). Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2). International journal of epidemiology, 52(4), 1086-1099. https://doi.org/10.1093/ije/dyad046

Harvey, SV, Wentzensen, N, Bertrand, K, Black, A, Brinton, LA, Chen, C, Costas, L, Maso, LD, De Vivo, I, Du, M, Garcia-Closas, M, Goodman, MT, Gorzelitz, J, Johnson, L, Lacey, JV, Liao, L, Lipworth, L, Lissowska, J, Miller, AB, O’Connell, K, O’Mara, TA, Ou, X, Palmer, JR, Patel, AV, Paytubi, S, Pelegrina, B, Petruzella, S, Prizment, A, Rohan, T, Sandin, S, Setiawan, VW, Sinha, R, Trabert, B, Webb, PM, Wilkens, LR, Xu, W, Yang, HP, Zheng, W & Clarke, MA 2023, 'Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)', International journal of epidemiology, vol. 52, no. 4, pp. 1086-1099. https://doi.org/10.1093/ije/dyad046

@article{8bf4f909caf142a694393d143cb54c32,

title = "Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)",

abstract = "Background: Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18–21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). Methods: We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. Results: We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR ¼ 2.85, 95% CI ¼ 2.47–3.29) and young adulthood (OR ¼ 1.26, 95% CI ¼ 1.06–1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Conclusions: Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.",

keywords = "BMI, BMI change, Endometrial cancer, epidemiology, gynaecology, life course exposures, obesity, uterine cancer, weight change, weight loss",

author = "Harvey, {Summer V.} and Nicolas Wentzensen and Kimberly Bertrand and Amanda Black and Brinton, {Louise A.} and Chu Chen and Laura Costas and Maso, {Luigino Dal} and {De Vivo}, Immaculata and Mengmeng Du and Montserrat Garcia-Closas and Goodman, {Marc T.} and Jessica Gorzelitz and Lisa Johnson and Lacey, {James V.} and Linda Liao and Loren Lipworth and Jolanta Lissowska and Miller, {Anthony B.} and Kelli O{\textquoteright}Connell and O{\textquoteright}Mara, {Tracy A.} and Xiao Ou and Palmer, {Julie R.} and Patel, {Alpa V.} and Sonia Paytubi and Beatriz Pelegrina and Stacey Petruzella and Anna Prizment and Thomas Rohan and Sven Sandin and Setiawan, {Veronica Wendy} and Rashmi Sinha and Britton Trabert and Webb, {Penelope M.} and Wilkens, {Lynne R.} and Wanghong Xu and Yang, {Hannah P.} and Wei Zheng and Clarke, {Megan A.}",

year = "2023",

month = aug,

day = "1",

doi = "10.1093/ije/dyad046",

language = "English (US)",

volume = "52",

pages = "1086--1099",

journal = "International journal of epidemiology",

issn = "0300-5771",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

AU - Harvey, Summer V.

AU - Wentzensen, Nicolas

AU - Bertrand, Kimberly

AU - Black, Amanda

AU - Brinton, Louise A.

AU - Chen, Chu

AU - Costas, Laura

AU - Maso, Luigino Dal

AU - De Vivo, Immaculata

AU - Du, Mengmeng

AU - Garcia-Closas, Montserrat

AU - Goodman, Marc T.

AU - Gorzelitz, Jessica

AU - Johnson, Lisa

AU - Lacey, James V.

AU - Liao, Linda

AU - Lipworth, Loren

AU - Lissowska, Jolanta

AU - Miller, Anthony B.

AU - O’Connell, Kelli

AU - O’Mara, Tracy A.

AU - Ou, Xiao

AU - Palmer, Julie R.

AU - Patel, Alpa V.

AU - Paytubi, Sonia

AU - Pelegrina, Beatriz

AU - Petruzella, Stacey

AU - Prizment, Anna

AU - Rohan, Thomas

AU - Sandin, Sven

AU - Setiawan, Veronica Wendy

AU - Sinha, Rashmi

AU - Trabert, Britton

AU - Webb, Penelope M.

AU - Wilkens, Lynne R.

AU - Xu, Wanghong

AU - Yang, Hannah P.

AU - Zheng, Wei

AU - Clarke, Megan A.

PY - 2023/8/1

Y1 - 2023/8/1

N2 - Background: Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18–21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). Methods: We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. Results: We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR ¼ 2.85, 95% CI ¼ 2.47–3.29) and young adulthood (OR ¼ 1.26, 95% CI ¼ 1.06–1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Conclusions: Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

AB - Background: Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18–21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). Methods: We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. Results: We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR ¼ 2.85, 95% CI ¼ 2.47–3.29) and young adulthood (OR ¼ 1.26, 95% CI ¼ 1.06–1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Conclusions: Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

KW - BMI

KW - BMI change

KW - Endometrial cancer

KW - epidemiology

KW - gynaecology

KW - life course exposures

KW - obesity

KW - uterine cancer

KW - weight change

KW - weight loss

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UR - http://www.scopus.com/inward/citedby.url?scp=85166442225&partnerID=8YFLogxK

U2 - 10.1093/ije/dyad046

DO - 10.1093/ije/dyad046

M3 - Article

C2 - 37029916

AN - SCOPUS:85166442225

SN - 0300-5771

VL - 52

SP - 1086

EP - 1099

JO - International journal of epidemiology

JF - International journal of epidemiology

IS - 4

ER -

Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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