TY - JOUR
T1 - Association of Later-LifeWeight ChangesWith Survival to Ages 90, 95, and 100:TheWomen’s Health Initiative
AU - Shadyab, Aladdin H.
AU - Manson, Jo Ann E.
AU - Allison, Matthew A.
AU - Laddu, Deepika
AU - Wassertheil-Smoller, Sylvia
AU - Van Horn, Linda
AU - Wild, Robert A.
AU - Banack, Hailey R.
AU - Tabung, Fred K.
AU - Haring, Bernhard
AU - Sun, Yangbo
AU - LeBlanc, Erin S.
AU - Wactawski-Wende, Jean
AU - LeBoff, Meryl S.
AU - Naughton, Michelle J.
AU - Luo, Juhua
AU - Schnatz, Peter F.
AU - Natale, Ginny
AU - Ostfeld, Robert J.
AU - LaCroix, Andrea Z.
N1 - Publisher Copyright:
© 2023 Oxford University Press. All rights reserved.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Background: Associations of weight changes and intentionality of weight loss with longevity are not well described. Methods: Using longitudinal data from the Women’s Health Initiative (N = 54 437; 61–81 years), we examined associations of weight changes and intentionality of weight loss with survival to ages 90, 95, and 100. Weight was measured at baseline, year 3, and year 10, and participants were classified as having weight loss (≥5% decrease from baseline), weight gain (≥5% increase from baseline), or stable weight (<5% change from baseline). Participants reported intentionality of weight loss at year 3. Results: A total of 30 647 (56.3%) women survived to ≥90 years. After adjustment for relevant covariates, 3-year weight loss of ≥5% vs stable weight was associated with lower odds of survival to ages 90 (OR, 0.67; 95% CI, 0.64–0.71), 95 (OR, 0.65; 95% CI, 0.60–0.71), and 100 (OR, 0.62; 95% CI, 0.49–0.78). Compared to intentional weight loss, unintentional weight loss was more strongly associated with lower odds of survival to age 90 (OR, 0.83; 95% CI, 0.74–0.94 and OR, 0.49; 95% CI, 0.44–0.55, respectively). Three-year weight gain of ≥5% vs stable weight was not associated with survival to age 90, 95, or 100.The pattern of results was similar among normal weight, overweight, and obese women in body mass index (BMI)-stratified analyses. Conclusions: Weight loss of ≥5% vs stable weight was associated with lower odds of longevity, more strongly for unintentional weight loss than for intentional weight loss. Potential inaccuracy of self-reported intentionality of weight loss and residual confounding were limitations.
AB - Background: Associations of weight changes and intentionality of weight loss with longevity are not well described. Methods: Using longitudinal data from the Women’s Health Initiative (N = 54 437; 61–81 years), we examined associations of weight changes and intentionality of weight loss with survival to ages 90, 95, and 100. Weight was measured at baseline, year 3, and year 10, and participants were classified as having weight loss (≥5% decrease from baseline), weight gain (≥5% increase from baseline), or stable weight (<5% change from baseline). Participants reported intentionality of weight loss at year 3. Results: A total of 30 647 (56.3%) women survived to ≥90 years. After adjustment for relevant covariates, 3-year weight loss of ≥5% vs stable weight was associated with lower odds of survival to ages 90 (OR, 0.67; 95% CI, 0.64–0.71), 95 (OR, 0.65; 95% CI, 0.60–0.71), and 100 (OR, 0.62; 95% CI, 0.49–0.78). Compared to intentional weight loss, unintentional weight loss was more strongly associated with lower odds of survival to age 90 (OR, 0.83; 95% CI, 0.74–0.94 and OR, 0.49; 95% CI, 0.44–0.55, respectively). Three-year weight gain of ≥5% vs stable weight was not associated with survival to age 90, 95, or 100.The pattern of results was similar among normal weight, overweight, and obese women in body mass index (BMI)-stratified analyses. Conclusions: Weight loss of ≥5% vs stable weight was associated with lower odds of longevity, more strongly for unintentional weight loss than for intentional weight loss. Potential inaccuracy of self-reported intentionality of weight loss and residual confounding were limitations.
KW - Longevity
KW - Obesity
KW - Successful aging
UR - http://www.scopus.com/inward/record.url?scp=85178651850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85178651850&partnerID=8YFLogxK
U2 - 10.1093/gerona/glad177
DO - 10.1093/gerona/glad177
M3 - Article
C2 - 37642339
AN - SCOPUS:85178651850
SN - 1079-5006
VL - 78
SP - 2264
EP - 2273
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 12
ER -