Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies

Dawn Q. Chong; Barbara L. Banbury; Amanda I. Phipps; Xinwei Hua; Jonathan Kocarnik; Ulrike Peters; Sonja I. Berndt; Wen Yi Huang; John D. Potter; Martha L. Slattery; Emily White; Peter T. Campbell; Tabitha Harrison; Polly A. Newcomb; Andrew T. Chan

doi:10.1002/cam4.1470

Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies

Dawn Q. Chong, Barbara L. Banbury, Amanda I. Phipps, Xinwei Hua, Jonathan Kocarnik, Ulrike Peters, Sonja I. Berndt, Wen Yi Huang, John D. Potter, Martha L. Slattery, Emily White, Peter T. Campbell, Tabitha Harrison, Polly A. Newcomb, Andrew T. Chan

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A family history of colorectal cancer (CRC) in first-degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC-specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival. Among CRC cases, 819 (16%) patients reported a family history of CRC. There were 1580 total deaths over a median follow-up of 4.6 years, of which 1046 (66%) deaths were due to CRC. Having a family history of CRC was not associated with OS [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.89–1.19] or CSS (HR, 1.13; 95% CI, 0.95–1.36)]. There were no associations between the number of affected relatives or age at CRC diagnosis of the affected relative with survival (all P _trend > 0.05). However, a family history of CRC did confer worse CSS in patients diagnosed with distal colon cancer (HR, 1.45, 95% CI, 1.03–2.04). A family history of CRC was generally not associated with survival after CRC diagnosis. However, having a family history of CRC was associated with worse CRC prognosis in individuals with distal colon cancer, suggesting a possible genetic predisposition with distinct pathogenic mechanism that may lead to worse survival in this group.

Original language	English (US)
Pages (from-to)	2192-2199
Number of pages	8
Journal	Cancer Medicine
Volume	7
Issue number	5
DOIs	https://doi.org/10.1002/cam4.1470
State	Published - May 2018
Externally published	Yes

Keywords

Colorectal cancer
family history
first-degree relative
mortality
survival

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/cam4.1470

Cite this

Chong, D. Q., Banbury, B. L., Phipps, A. I., Hua, X., Kocarnik, J., Peters, U., Berndt, S. I., Huang, W. Y., Potter, J. D., Slattery, M. L., White, E., Campbell, P. T., Harrison, T., Newcomb, P. A., & Chan, A. T. (2018). Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies. Cancer Medicine, 7(5), 2192-2199. https://doi.org/10.1002/cam4.1470

Chong, DQ, Banbury, BL, Phipps, AI, Hua, X, Kocarnik, J, Peters, U, Berndt, SI, Huang, WY, Potter, JD, Slattery, ML, White, E, Campbell, PT, Harrison, T, Newcomb, PA & Chan, AT 2018, 'Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies', Cancer Medicine, vol. 7, no. 5, pp. 2192-2199. https://doi.org/10.1002/cam4.1470

@article{2e31c53694ef4b0ea15ae83d3c316dca,

title = "Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies",

abstract = " A family history of colorectal cancer (CRC) in first-degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC-specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival. Among CRC cases, 819 (16%) patients reported a family history of CRC. There were 1580 total deaths over a median follow-up of 4.6 years, of which 1046 (66%) deaths were due to CRC. Having a family history of CRC was not associated with OS [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.89–1.19] or CSS (HR, 1.13; 95% CI, 0.95–1.36)]. There were no associations between the number of affected relatives or age at CRC diagnosis of the affected relative with survival (all P trend > 0.05). However, a family history of CRC did confer worse CSS in patients diagnosed with distal colon cancer (HR, 1.45, 95% CI, 1.03–2.04). A family history of CRC was generally not associated with survival after CRC diagnosis. However, having a family history of CRC was associated with worse CRC prognosis in individuals with distal colon cancer, suggesting a possible genetic predisposition with distinct pathogenic mechanism that may lead to worse survival in this group.",

keywords = "Colorectal cancer, family history, first-degree relative, mortality, survival",

author = "Chong, {Dawn Q.} and Banbury, {Barbara L.} and Phipps, {Amanda I.} and Xinwei Hua and Jonathan Kocarnik and Ulrike Peters and Berndt, {Sonja I.} and Huang, {Wen Yi} and Potter, {John D.} and Slattery, {Martha L.} and Emily White and Campbell, {Peter T.} and Tabitha Harrison and Newcomb, {Polly A.} and Chan, {Andrew T.}",

note = "Funding Information: This work is supported by the National Cancer Institute (NCI) (R01 CA176272, K07CA172298) and the National Center for Advancing Translational Sciences (KL2 TR000421), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS); Cancer Prevention Study-II (CPS-II) is supported by the American Cancer Society; Diet, Activity and Lifestyle Study (DALS) is supported by the NIH (R01 CA48998); Health Professionals Follow-up Study (HPFS) is supported by the NIH (P01 CA 055075, UM1 CA167552, R01 137178, R01 CA151993 and P50 CA127003); Nurses{\textquoteright} Health Study (NHS) is supported by the NIH (UM1 CA186107, R01 CA137178, P01 CA87969, R01 CA151993 and P50 CA127003); Prostate, Lung, Colorectal and Funding Information: Ovarian Cancer Screening Trial (PLCO) is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, and the Division of Cancer Prevention, NCI, NIH, DHHS; Post-Menopausal Hormone Study within the Colorectal Cancer Family Registry (PMH-CCFR) is supported by NIH (R01 CA076366); Women{\textquoteright}s Health Initiative (WHI) is supported by the National Heart, Lung, and Blood Institute, NIH, DHHS through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. Funding Information: The authors thank the participants of CPS-II, HPFS, NHS, PLCO, VITAL, WHI, PMH-CCFR, and DALS, and the cancer registries supported through the Centers for Disease Control, Prevention National Program of Cancer Registries, and the National Cancer Institute Surveillance Epidemiology and End Results program. Publisher Copyright: {\textcopyright} 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.",

year = "2018",

month = may,

doi = "10.1002/cam4.1470",

language = "English (US)",

volume = "7",

pages = "2192--2199",

journal = "Cancer Medicine",

issn = "2045-7634",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Association of family history and survival in patients with colorectal cancer

T2 - a pooled analysis of eight epidemiologic studies

AU - Chong, Dawn Q.

AU - Banbury, Barbara L.

AU - Phipps, Amanda I.

AU - Hua, Xinwei

AU - Kocarnik, Jonathan

AU - Peters, Ulrike

AU - Berndt, Sonja I.

AU - Huang, Wen Yi

AU - Potter, John D.

AU - Slattery, Martha L.

AU - White, Emily

AU - Campbell, Peter T.

AU - Harrison, Tabitha

AU - Newcomb, Polly A.

AU - Chan, Andrew T.

N1 - Funding Information: This work is supported by the National Cancer Institute (NCI) (R01 CA176272, K07CA172298) and the National Center for Advancing Translational Sciences (KL2 TR000421), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS); Cancer Prevention Study-II (CPS-II) is supported by the American Cancer Society; Diet, Activity and Lifestyle Study (DALS) is supported by the NIH (R01 CA48998); Health Professionals Follow-up Study (HPFS) is supported by the NIH (P01 CA 055075, UM1 CA167552, R01 137178, R01 CA151993 and P50 CA127003); Nurses’ Health Study (NHS) is supported by the NIH (UM1 CA186107, R01 CA137178, P01 CA87969, R01 CA151993 and P50 CA127003); Prostate, Lung, Colorectal and Funding Information: Ovarian Cancer Screening Trial (PLCO) is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, and the Division of Cancer Prevention, NCI, NIH, DHHS; Post-Menopausal Hormone Study within the Colorectal Cancer Family Registry (PMH-CCFR) is supported by NIH (R01 CA076366); Women’s Health Initiative (WHI) is supported by the National Heart, Lung, and Blood Institute, NIH, DHHS through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. Funding Information: The authors thank the participants of CPS-II, HPFS, NHS, PLCO, VITAL, WHI, PMH-CCFR, and DALS, and the cancer registries supported through the Centers for Disease Control, Prevention National Program of Cancer Registries, and the National Cancer Institute Surveillance Epidemiology and End Results program. Publisher Copyright: © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

PY - 2018/5

Y1 - 2018/5

N2 - A family history of colorectal cancer (CRC) in first-degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC-specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival. Among CRC cases, 819 (16%) patients reported a family history of CRC. There were 1580 total deaths over a median follow-up of 4.6 years, of which 1046 (66%) deaths were due to CRC. Having a family history of CRC was not associated with OS [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.89–1.19] or CSS (HR, 1.13; 95% CI, 0.95–1.36)]. There were no associations between the number of affected relatives or age at CRC diagnosis of the affected relative with survival (all P trend > 0.05). However, a family history of CRC did confer worse CSS in patients diagnosed with distal colon cancer (HR, 1.45, 95% CI, 1.03–2.04). A family history of CRC was generally not associated with survival after CRC diagnosis. However, having a family history of CRC was associated with worse CRC prognosis in individuals with distal colon cancer, suggesting a possible genetic predisposition with distinct pathogenic mechanism that may lead to worse survival in this group.

AB - A family history of colorectal cancer (CRC) in first-degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC-specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival. Among CRC cases, 819 (16%) patients reported a family history of CRC. There were 1580 total deaths over a median follow-up of 4.6 years, of which 1046 (66%) deaths were due to CRC. Having a family history of CRC was not associated with OS [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.89–1.19] or CSS (HR, 1.13; 95% CI, 0.95–1.36)]. There were no associations between the number of affected relatives or age at CRC diagnosis of the affected relative with survival (all P trend > 0.05). However, a family history of CRC did confer worse CSS in patients diagnosed with distal colon cancer (HR, 1.45, 95% CI, 1.03–2.04). A family history of CRC was generally not associated with survival after CRC diagnosis. However, having a family history of CRC was associated with worse CRC prognosis in individuals with distal colon cancer, suggesting a possible genetic predisposition with distinct pathogenic mechanism that may lead to worse survival in this group.

KW - Colorectal cancer

KW - family history

KW - first-degree relative

KW - mortality

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85044480422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044480422&partnerID=8YFLogxK

U2 - 10.1002/cam4.1470

DO - 10.1002/cam4.1470

M3 - Article

C2 - 29582567

AN - SCOPUS:85044480422

SN - 2045-7634

VL - 7

SP - 2192

EP - 2199

JO - Cancer Medicine

JF - Cancer Medicine

IS - 5

ER -

Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this