TY - JOUR
T1 - Association of Antibodies to Gm and Antibodies to Australia Antigen in Adolescent Drug Addicts
AU - Nathenson, Gerald
AU - Cohen, Michael I.
AU - Millman, Irving
AU - Blumberg, Baruch S.
PY - 1974/2
Y1 - 1974/2
N2 - A 7.7% incidence of antibodies directed against Gm (a), Gm (b) and Gm (f) antigens of IgG was noted in 298 adolescent drug addicts, as compared to 0.9% in a nonaddicted control group. Isoimmunization as a stimulus for Gm antibody production in addicts was indirectly excluded. A significant association between anti-Au and anti-Gm in the sera of drug addicts was found, which suggests that the hepatitis agent associated with Australia antigen may be responsible for the induction of Gm antibodies in this group. The authors thank Dr. Parvez Lalezari for the red blood cell antibody determinations. This work was supported, in part, by the American Cancer Society Institutional Research Grant IN-28L, by USPHS Grants CA-06551, CA-06927, RR-05539 and Contract No. 70-2234B from the National Institutes of Health, and by an appropriation from the Commonwealth of Pennsylvania.
AB - A 7.7% incidence of antibodies directed against Gm (a), Gm (b) and Gm (f) antigens of IgG was noted in 298 adolescent drug addicts, as compared to 0.9% in a nonaddicted control group. Isoimmunization as a stimulus for Gm antibody production in addicts was indirectly excluded. A significant association between anti-Au and anti-Gm in the sera of drug addicts was found, which suggests that the hepatitis agent associated with Australia antigen may be responsible for the induction of Gm antibodies in this group. The authors thank Dr. Parvez Lalezari for the red blood cell antibody determinations. This work was supported, in part, by the American Cancer Society Institutional Research Grant IN-28L, by USPHS Grants CA-06551, CA-06927, RR-05539 and Contract No. 70-2234B from the National Institutes of Health, and by an appropriation from the Commonwealth of Pennsylvania.
UR - http://www.scopus.com/inward/record.url?scp=0015994043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015994043&partnerID=8YFLogxK
U2 - 10.3181/00379727-145-37810
DO - 10.3181/00379727-145-37810
M3 - Article
C2 - 4544388
AN - SCOPUS:0015994043
SN - 0037-9727
VL - 145
SP - 358
EP - 360
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -