TY - JOUR
T1 - Association of Acculturation and Hispanic/Latino Background with Endogenous Sex and Thyroid-Related Hormones Among Middle-Aged and Older Hispanic/Latino Adults
T2 - the HCHS/SOL Study
AU - Abasilim, Chibuzor
AU - Persky, Victoria
AU - Sargis, Robert M.
AU - Argos, Maria
AU - Daviglus, Martha L.
AU - Freels, Sally
AU - Tsintsifas, Konstantina
AU - Day, Tessa
AU - Cai, Jianwen
AU - Isasi, Carmen R.
AU - Peters, Brandilyn A.
AU - Talavera, Gregory A.
AU - Thyagarajan, Bharat
AU - Turyk, Mary E.
N1 - Publisher Copyright:
© 2023, W. Montague Cobb-NMA Health Institute.
PY - 2023
Y1 - 2023
N2 - Background: Hormones are linked to cardiometabolic diseases and may be impacted by acculturation though multiple mechanisms. We evaluated associations of Hispanic/Latino background and acculturation with levels of sex- and thyroid-related hormones and the potential mediating effect of adiposity, lifestyle factors, and sleep apnea syndrome on these associations. Methods: We studied 1789 adults, aged 45–74, from a sub-cohort of the Hispanic Community Health Survey/Study of Latinos. Peri/pre-menopausal women and individuals on medications related to hormones were excluded. Our study assessed eleven sex- and thyroid-related hormones, Hispanic/Latino background, and five acculturation measures. Associations were assessed using multivariable linear and logistic regression adjusted for survey design and confounding variables. We explored potential mediation using a path analysis. Results: In postmenopausal women, acculturation score-MESA was associated with decreased thyroid-stimulating hormone (β = − 0.13;95%CI = − 0.22, − 0.03) while age at immigration greater than the median (vs US-born) was associated with decreased (β = − 14.6; 95%CI = − 28.2, − 0.99) triiodothyronine (T3). In men, language acculturation and acculturation score-MESA were associated with increased estradiol and sex hormone-binding globulin (SHBG) while age at immigration greater and lesser than the median (vs US-born) was associated with decreased SHBG. Hispanic/Latino background (Mexicans as reference) were selectively associated with sex- and thyroid-related hormone levels in both sexes. Current smoking and sleep apnea syndrome partially mediated the association of Cuban and Puerto Rican heritage (vs Mexican) with T3 levels in men and postmenopausal women, respectively. Conclusion: Selected acculturation measures were associated with thyroid-related hormones in postmenopausal women and sex-related hormones in men. Understanding the mechanisms involved in the relationship of acculturation and Hispanic/Latino background with hormones warrants additional investigation.
AB - Background: Hormones are linked to cardiometabolic diseases and may be impacted by acculturation though multiple mechanisms. We evaluated associations of Hispanic/Latino background and acculturation with levels of sex- and thyroid-related hormones and the potential mediating effect of adiposity, lifestyle factors, and sleep apnea syndrome on these associations. Methods: We studied 1789 adults, aged 45–74, from a sub-cohort of the Hispanic Community Health Survey/Study of Latinos. Peri/pre-menopausal women and individuals on medications related to hormones were excluded. Our study assessed eleven sex- and thyroid-related hormones, Hispanic/Latino background, and five acculturation measures. Associations were assessed using multivariable linear and logistic regression adjusted for survey design and confounding variables. We explored potential mediation using a path analysis. Results: In postmenopausal women, acculturation score-MESA was associated with decreased thyroid-stimulating hormone (β = − 0.13;95%CI = − 0.22, − 0.03) while age at immigration greater than the median (vs US-born) was associated with decreased (β = − 14.6; 95%CI = − 28.2, − 0.99) triiodothyronine (T3). In men, language acculturation and acculturation score-MESA were associated with increased estradiol and sex hormone-binding globulin (SHBG) while age at immigration greater and lesser than the median (vs US-born) was associated with decreased SHBG. Hispanic/Latino background (Mexicans as reference) were selectively associated with sex- and thyroid-related hormone levels in both sexes. Current smoking and sleep apnea syndrome partially mediated the association of Cuban and Puerto Rican heritage (vs Mexican) with T3 levels in men and postmenopausal women, respectively. Conclusion: Selected acculturation measures were associated with thyroid-related hormones in postmenopausal women and sex-related hormones in men. Understanding the mechanisms involved in the relationship of acculturation and Hispanic/Latino background with hormones warrants additional investigation.
KW - Acculturation
KW - Hispanic/Latino
KW - Mediation
KW - Sex hormones
KW - Structural equation model
KW - Thyroid hormones
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U2 - 10.1007/s40615-023-01762-8
DO - 10.1007/s40615-023-01762-8
M3 - Article
AN - SCOPUS:85168624520
SN - 2197-3792
JO - Journal of Racial and Ethnic Health Disparities
JF - Journal of Racial and Ethnic Health Disparities
ER -
