Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

Michael Fattouh; Gina Y. Chang; Thomas J. Ow; Keivan Shifteh; Gregory Rosenblatt; Viraj M. Patel; Richard V. Smith; Michael B. Prystowsky; Nicolas F. Schlecht

doi:10.1002/hed.25420

Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

Michael Fattouh, Gina Y. Chang, Thomas J. Ow, Keivan Shifteh, Gregory Rosenblatt, Viraj M. Patel, Richard V. Smith, Michael B. Prystowsky, Nicolas F. Schlecht

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.

Original language	English (US)
Pages (from-to)	707-714
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	3
DOIs	https://doi.org/10.1002/hed.25420
State	Published - Mar 1 2019

Keywords

body mass index
epidemiology
obesity
sarcopenia
survival

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/hed.25420

Cite this

@article{64bc2486bd8f4f8ebd47483028d21138,

title = "Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer",

abstract = "Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.",

keywords = "body mass index, epidemiology, obesity, sarcopenia, survival",

author = "Michael Fattouh and Chang, {Gina Y.} and Ow, {Thomas J.} and Keivan Shifteh and Gregory Rosenblatt and Patel, {Viraj M.} and Smith, {Richard V.} and Prystowsky, {Michael B.} and Schlecht, {Nicolas F.}",

note = "Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2019",

month = mar,

day = "1",

doi = "10.1002/hed.25420",

language = "English (US)",

volume = "41",

pages = "707--714",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "3",

}

TY - JOUR

T1 - Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

AU - Fattouh, Michael

AU - Chang, Gina Y.

AU - Ow, Thomas J.

AU - Shifteh, Keivan

AU - Rosenblatt, Gregory

AU - Patel, Viraj M.

AU - Smith, Richard V.

AU - Prystowsky, Michael B.

AU - Schlecht, Nicolas F.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.

AB - Background: Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression. Methods: We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for differences in survival adjusting for comorbid conditions (cardiovascular disease and diabetes). Evidence of sarcopenia was also assessed using pretreatment abdominal CT scans in a subset of 113 patients. Results: Prior to treatment, 55% of HNSCC patients were overweight or obese. Overweight/obese patients had significantly better overall survival (hazard ratio [HR] = 0.4, 95% CI: 0.3-0.6) compared to normal-weight patients, independent of comorbid conditions. Patients with sarcopenia had significantly poorer survival (HR = 2.1, 95% CI: 1.1-3.9) compared to non-sarcopenic patients, with the strongest association seen among overweight/obese patients. Conclusion: Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.

KW - body mass index

KW - epidemiology

KW - obesity

KW - sarcopenia

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=85058996974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058996974&partnerID=8YFLogxK

U2 - 10.1002/hed.25420

DO - 10.1002/hed.25420

M3 - Article

C2 - 30582237

AN - SCOPUS:85058996974

SN - 1043-3074

VL - 41

SP - 707

EP - 714

JO - Head and Neck

JF - Head and Neck

IS - 3

ER -

Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this