Association between healthy eating patterns and risk of cardiovascular disease

Zhilei Shan, Yanping Li, Megu Y. Baden, Shilpa N. Bhupathiraju, Dong D. Wang, Qi Sun, Kathryn M. Rexrode, Eric B. Rimm, Lu Qi, Walter C. Willett, Jo Ann E. Manson, Qibin Qi, Frank B. Hu

Research output: Contribution to journalArticlepeer-review

169 Scopus citations


Importance: The 2015-2020 Dietary Guidelines for Americans recommend multiple healthy eating patterns. However, few studies have examined the associations of adherence to different dietary patterns with long-term risk of cardiovascular disease (CVD). Objective: To examine the associations of dietary scores for 4 healthy eating patterns with risk of incident CVD. Design, Setting, and Participants: Prospective cohort study of initially healthy women from the Nurses' Health Study (NHS) (1984-2016) and the NHS II (1991-2017) and men from the Health Professionals Follow-up Study (HPFS) (1986-2012). The dates of analysis were July 25 to December 4, 2019. Exposures: Healthy Eating Index-2015 (HEI-2015), Alternate Mediterranean Diet Score (AMED), Healthful Plant-Based Diet Index (HPDI), and Alternate Healthy Eating Index (AHEI). Main Outcomes and Measures: Cardiovascular disease events, including fatal and nonfatal coronary heart disease (CHD) and stroke. Results: The final study sample included 74930 women in the NHS (mean [SD] baseline age, 50.2 [7.2] years), 90864 women in the NHS II (mean [SD] baseline age, 36.1 [4.7] years), and 43339 men in the HPFS (mean [SD] baseline age, 53.2 [9.6] years). During a total of 5257190 person-years of follow-up, 23366 incident CVD cases were documented (18092 CHD and 5687 stroke) (some individuals were diagnosed as having both CHD and stroke). Comparing the highest with the lowest quintiles, the pooled multivariable-adjusted hazard ratios (HRs) of CVD were 0.83 (95% CI, 0.79-0.86) for the HEI-2015, 0.83 (95% CI, 0.79-0.86) for the AMED, 0.86 (95% CI, 0.82-0.89) for the HPDI, and 0.79 (95% CI, 0.75-0.82) for the AHEI (P for trend <.001 for all). In addition, a 25-percentile higher dietary score was associated with 10% to 20% lower risk of CVD (pooled HR, 0.80 [95% CI, 0.77-0.83] for the HEI-2015; 0.90 [95% CI, 0.87-0.92] for the AMED; 0.86 [95% CI, 0.82-0.89] for the HPDI; and 0.81 [95% CI, 0.78-0.84] for the AHEI). These dietary scores were statistically significantly associated with lower risk of both CHD and stroke. In analyses stratified by race/ethnicity and other potential risk factors for CVD, the inverse associations between these scores and risk of CVD were consistent in most subgroups. Conclusions and Relevance: In 3 large prospective cohorts with up to 32 years of follow-up, greater adherence to various healthy eating patterns was consistently associated with lower risk of CVD. These findings support the recommendations of the 2015-2020 Dietary Guidelines for Americans that multiple healthy eating patterns can be adapted to individual food traditions and preferences..

Original languageEnglish (US)
Pages (from-to)1090-1100
Number of pages11
JournalJAMA Internal Medicine
Issue number8
StatePublished - Aug 2020

ASJC Scopus subject areas

  • Internal Medicine


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