TY - JOUR
T1 - Association between bullous pemphigoid and malignancy
T2 - A meta-analysis
AU - Lucariello, Richard J.
AU - Villablanca, Salvadore E.
AU - Mascaró, José M.
AU - Reichel, Martin
N1 - Publisher Copyright:
© 2018 The Australasian College of Dermatologists
PY - 2018/11
Y1 - 2018/11
N2 - It has been suggested that bullous pemphigoid is associated with an increased risk of malignancy, but the evidence is inconsistent. Therefore, a meta-analysis was conducted to explore this association. PUBMED and Embase were searched for studies investigating the association between bullous pemphigoid and malignancy. This meta-analysis included 16 studies with a total of 9398 cases of bullous pemphigoid. The rate of malignancy in patients with bullous pemphigoid was 11% (95% CI: 9–14, P < 0.001); 9% (95% CI: 6–13, P < 0.003) for women and 13% (95% CI: 9–18, P < 0.03) for men, with a statistically insignificant higher risk in men (OR = 1.30, 95% CI: 0.99–1.71, P = 0.06). The event rate was 9% (95% CI: 5–14, P < 0.001) in the Asian population and 13% (95% CI: 10–17, P < 0.001) in the European population, with a statistically significant lower risk in the Asians population (OR = 0.69, 95% CI: 0.57–0.84; P < 0.001). The event rate of malignancy was higher in patients with bullous pemphigoid than in matched controls (OR = 2.08, 95% CI: 1.22–3.55; P = 0.005). The overall event rate of malignancy was higher in the bullous pemphigoid group than in matched controls. Caution is required when interpreting these results, as potential confounding variables were not controlled for.
AB - It has been suggested that bullous pemphigoid is associated with an increased risk of malignancy, but the evidence is inconsistent. Therefore, a meta-analysis was conducted to explore this association. PUBMED and Embase were searched for studies investigating the association between bullous pemphigoid and malignancy. This meta-analysis included 16 studies with a total of 9398 cases of bullous pemphigoid. The rate of malignancy in patients with bullous pemphigoid was 11% (95% CI: 9–14, P < 0.001); 9% (95% CI: 6–13, P < 0.003) for women and 13% (95% CI: 9–18, P < 0.03) for men, with a statistically insignificant higher risk in men (OR = 1.30, 95% CI: 0.99–1.71, P = 0.06). The event rate was 9% (95% CI: 5–14, P < 0.001) in the Asian population and 13% (95% CI: 10–17, P < 0.001) in the European population, with a statistically significant lower risk in the Asians population (OR = 0.69, 95% CI: 0.57–0.84; P < 0.001). The event rate of malignancy was higher in patients with bullous pemphigoid than in matched controls (OR = 2.08, 95% CI: 1.22–3.55; P = 0.005). The overall event rate of malignancy was higher in the bullous pemphigoid group than in matched controls. Caution is required when interpreting these results, as potential confounding variables were not controlled for.
KW - bullous pemphigoid
KW - malignancy
KW - meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=85053398225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053398225&partnerID=8YFLogxK
U2 - 10.1111/ajd.12764
DO - 10.1111/ajd.12764
M3 - Review article
C2 - 29313891
AN - SCOPUS:85053398225
SN - 0004-8380
VL - 59
SP - 253
EP - 260
JO - Australasian Journal of Dermatology
JF - Australasian Journal of Dermatology
IS - 4
ER -