Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

Helmuth H.G. van Es; A. Bout; J. Liu; L. Anderson; A. M.V. Duncan; P. Bosma; R. Oude Elferink; P. L.M. Jansen; J. Roy Chowdhury; E. Schurr

doi:10.1159/000133513

Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

Helmuth H.G. van Es, A. Bout, J. Liu, L. Anderson, A. M.V. Duncan, P. Bosma, R. Oude Elferink, P. L.M. Jansen, J. Roy Chowdhury, E. Schurr

Medicine

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Abstract

UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1 A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.

Original language	English (US)
Pages (from-to)	114-116
Number of pages	3
Journal	Cytogenetics and Cell Genetics
Volume	63
Issue number	2
DOIs	https://doi.org/10.1159/000133513
State	Published - 1993

ASJC Scopus subject areas

Genetics
Cell Biology

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title = "Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37",

abstract = "UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1 A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.",

author = "{van Es}, {Helmuth H.G.} and A. Bout and J. Liu and L. Anderson and Duncan, {A. M.V.} and P. Bosma and {Oude Elferink}, R. and Jansen, {P. L.M.} and Chowdhury, {J. Roy} and E. Schurr",

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language = "English (US)",

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T1 - Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

AU - van Es, Helmuth H.G.

AU - Bout, A.

AU - Liu, J.

AU - Anderson, L.

AU - Duncan, A. M.V.

AU - Bosma, P.

AU - Oude Elferink, R.

AU - Jansen, P. L.M.

AU - Chowdhury, J. Roy

AU - Schurr, E.

PY - 1993

Y1 - 1993

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AB - UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1 A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.

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Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37

Abstract

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