TY - JOUR
T1 - Assessment of the ototoxicity of docusate sodium (Colace) in a guinea pig animal model
AU - Emami, Nader
AU - Ng, Barbara
AU - Roskies, Michael
AU - Wazqar, Lana
AU - Makhoul, Georges
AU - Citra, Dan
AU - Daniel, Sam J.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/10
Y1 - 2012/10
N2 - Objective: Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to assess the safety of ototopic docusate sodium on hearing in the presence of TM perforation. Study Design: A prospective, randomized, controlled trial in a guinea pig animal model. Materials and Methods: Ten guinea pigs underwent bilateral myringotomy. In each animal, one ear received docusate sodium, serving as the experimental ear, and the other received normal saline as the control. Auditory brain response (ABR) was performed at baseline and then 1, 7, and 14 days following the application. Results: At day 14 following application, there was no significant change in ABR thresholds at 8, 12, 16, 20, or 25 kHz. Conclusion: In guinea pigs with perforated TMs, docusate sodium does not seem to cause ototoxicity. Future clinical studies are required.
AB - Objective: Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to assess the safety of ototopic docusate sodium on hearing in the presence of TM perforation. Study Design: A prospective, randomized, controlled trial in a guinea pig animal model. Materials and Methods: Ten guinea pigs underwent bilateral myringotomy. In each animal, one ear received docusate sodium, serving as the experimental ear, and the other received normal saline as the control. Auditory brain response (ABR) was performed at baseline and then 1, 7, and 14 days following the application. Results: At day 14 following application, there was no significant change in ABR thresholds at 8, 12, 16, 20, or 25 kHz. Conclusion: In guinea pigs with perforated TMs, docusate sodium does not seem to cause ototoxicity. Future clinical studies are required.
KW - Ceruminolytic
KW - Colace
KW - Docusate sodium
KW - Ototoxicity
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U2 - 10.2310/7070.2012.00044
DO - 10.2310/7070.2012.00044
M3 - Article
C2 - 23092833
AN - SCOPUS:84868242153
SN - 1916-0208
VL - 41
SP - 316
EP - 319
JO - Journal of Otolaryngology - Head and Neck Surgery
JF - Journal of Otolaryngology - Head and Neck Surgery
IS - 5
ER -