Assessment of the ototoxicity of docusate sodium (Colace) in a guinea pig animal model

Nader Emami, Barbara Ng, Michael Roskies, Lana Wazqar, Georges Makhoul, Dan Citra, Sam J. Daniel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to assess the safety of ototopic docusate sodium on hearing in the presence of TM perforation. Study Design: A prospective, randomized, controlled trial in a guinea pig animal model. Materials and Methods: Ten guinea pigs underwent bilateral myringotomy. In each animal, one ear received docusate sodium, serving as the experimental ear, and the other received normal saline as the control. Auditory brain response (ABR) was performed at baseline and then 1, 7, and 14 days following the application. Results: At day 14 following application, there was no significant change in ABR thresholds at 8, 12, 16, 20, or 25 kHz. Conclusion: In guinea pigs with perforated TMs, docusate sodium does not seem to cause ototoxicity. Future clinical studies are required.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalJournal of Otolaryngology - Head and Neck Surgery
Issue number5
StatePublished - Oct 2012
Externally publishedYes


  • Ceruminolytic
  • Colace
  • Docusate sodium
  • Ototoxicity

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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