TY - JOUR
T1 - Assessment of multiple task activation and reproducibility in patients with benign and low-grade neoplasms
AU - McKinsey, Rachel D.
AU - Moritz, C. H.
AU - Meyerand, M. E.
AU - Tomé, W. A.
PY - 2010/8
Y1 - 2010/8
N2 - Twenty-four patients with proven benign and low-grade brain neoplasms each performed two iterations of four fMRI paradigms: language (word generation), primary and associa tion auditory (text listening), upper limb fine motor control (alternating-limb bilateral finger tapping), and primary visual perception (reversing checkerboard). Activation clusters with varying thresholds were generated for each scan and used to calculate reproducibility parameters: Difference in the Center of Mass (COM) location, Rsize, and R overlap. The average difference in the COM, Rsize, and Roverlap values ranged from 1.70 ± 0.53 mm -10.60 ± 3.21 mm, 0.6 ± 0.04-0.90 ± 0.05 and 0.23 ± 0.12 -1 ± 0.16 respectively for all tasks. These values are within the range of, or higher than, previously published reports on fMRI test-retest precision. FMRI is indicated to be a noninvasive tool with acceptable reproducibility measures for assessing the localizations of multiple language and sensorimotor functions in patients scheduled for radiotherapy treatment.
AB - Twenty-four patients with proven benign and low-grade brain neoplasms each performed two iterations of four fMRI paradigms: language (word generation), primary and associa tion auditory (text listening), upper limb fine motor control (alternating-limb bilateral finger tapping), and primary visual perception (reversing checkerboard). Activation clusters with varying thresholds were generated for each scan and used to calculate reproducibility parameters: Difference in the Center of Mass (COM) location, Rsize, and R overlap. The average difference in the COM, Rsize, and Roverlap values ranged from 1.70 ± 0.53 mm -10.60 ± 3.21 mm, 0.6 ± 0.04-0.90 ± 0.05 and 0.23 ± 0.12 -1 ± 0.16 respectively for all tasks. These values are within the range of, or higher than, previously published reports on fMRI test-retest precision. FMRI is indicated to be a noninvasive tool with acceptable reproducibility measures for assessing the localizations of multiple language and sensorimotor functions in patients scheduled for radiotherapy treatment.
KW - Benign and low-grade brain neoplasms
KW - Blood oxygen level dependent
KW - Reproducibility
KW - fMRI
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U2 - 10.1177/153303461000900402
DO - 10.1177/153303461000900402
M3 - Article
C2 - 20626198
AN - SCOPUS:77956542071
SN - 1533-0346
VL - 9
SP - 319
EP - 326
JO - Technology in Cancer Research and Treatment
JF - Technology in Cancer Research and Treatment
IS - 4
ER -