Aspiration occurence during chemoradiation for head and neck cancer

Nam P. Nguyen; Herbert J. Smith; Suresh Dutta; Alan Alfieri; Debra North; Phuc D. Nguyen; L. E.E. Howard; Tomas Martinez; Claire Lemanski; Adir Ludin; Ly M. Nguyen; Sabah Sallah

Aspiration occurence during chemoradiation for head and neck cancer

Nam P. Nguyen, Herbert J. Smith, Suresh Dutta, Alan Alfieri, Debra North, Phuc D. Nguyen, L. E.E. Howard, Tomas Martinez, Claire Lemanski, Adir Ludin, Ly M. Nguyen, Sabah Sallah

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.

Original language	English (US)
Pages (from-to)	1669-1672
Number of pages	4
Journal	Anticancer Research
Volume	27
Issue number	3 B
State	Published - May 1 2007

Keywords

Aspiration
Chemoradiation
Head and neck cancer
Pneumonia
Swallow

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Aspiration occurence during chemoradiation for head and neck cancer",

abstract = "Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.",

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author = "Nguyen, {Nam P.} and Smith, {Herbert J.} and Suresh Dutta and Alan Alfieri and Debra North and Nguyen, {Phuc D.} and Howard, {L. E.E.} and Tomas Martinez and Claire Lemanski and Adir Ludin and Nguyen, {Ly M.} and Sabah Sallah",

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AU - Nguyen, Nam P.

AU - Smith, Herbert J.

AU - Dutta, Suresh

AU - Alfieri, Alan

AU - North, Debra

AU - Nguyen, Phuc D.

AU - Howard, L. E.E.

AU - Martinez, Tomas

AU - Lemanski, Claire

AU - Ludin, Adir

AU - Nguyen, Ly M.

AU - Sallah, Sabah

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.

AB - Aim: To assess the risk of developing aspiration during chemoradiation for head and neck cancer. Patients and Methods: A retrospective review of 114 patients who underwent concurrent chemoradiation for locally advanced head and neck cancer was undertaken. Patients were determined as having aspiration if they had pneumonia on chest-X-ray (CXR) and/or had documented aspiration on the modified barium swallow (MBS) during their treatment. Results: Fifteen patients (13%) developed aspiration during chemoradiation. Twelve patients (10%) had aspiration demonstrated on CXR alone (9 patients) or combined with MBS (3 patients). Three patients (3%) had aspiration on MBS alone. Three of the six patients with aspiration observed on MBS had normal swallowing on their pretreatment MBS. All 15 patients had severe mucositis and neutropenia at the time of the aspiration. Despite broad-spectrum antibiotics and supportive care, six patients (5%) died. Conclusion: Aspiration may develop during chemoradiation for head and neck cancer because of radiation-induced altered swallow.

KW - Aspiration

KW - Chemoradiation

KW - Head and neck cancer

KW - Pneumonia

KW - Swallow

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Aspiration occurence during chemoradiation for head and neck cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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