Asp-to-Asn Substitution at the First Position of the DxD TOPRIM Motif of Recombinant Bacterial Topoisomerase I Is Extremely Lethal to E. coli

Bokun Cheng, Thirunavukkarasu Annamalai, Elena Sorokin, Maria Abrenica, Sandra Aedo, Yuk Ching Tse-Dinh

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Medicine & Life Sciences