Ashkenazi Jewish Screening in the Twenty-first Century

Susan Klugman, Susan J. Gross

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Ashkenazi Jewish genetic screening has expanded significantly in the past 4 decades. Individuals of Eastern European (Ashkenazi) Jewish (AJ) descent are at increased risk of having offspring with particular genetic diseases that have significant morbidity and mortality. In addition, there are some disorders, such as cystic fibrosis, for which northern European Caucasians are at comparable risk with those of an AJ background. Carrier screening for many of these Jewish genetic disorders has become standard of care. As technology advances, so does the number of disorders for which screening is available. Thus, we need to continue to be cognizant of informed consent, test sensitivity, confidentiality, prenatal diagnosis, preimplantation genetic screening, and public health concerns regarding testing.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalObstetrics and Gynecology Clinics of North America
Issue number1
StatePublished - Mar 2010


  • Ashkenazi Jewish genetic screening
  • Carrier screening
  • Jewish genetic disorders

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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