Abstract
Ashkenazi Jewish genetic screening has expanded significantly in the past 4 decades. Individuals of Eastern European (Ashkenazi) Jewish (AJ) descent are at increased risk of having offspring with particular genetic diseases that have significant morbidity and mortality. In addition, there are some disorders, such as cystic fibrosis, for which northern European Caucasians are at comparable risk with those of an AJ background. Carrier screening for many of these Jewish genetic disorders has become standard of care. As technology advances, so does the number of disorders for which screening is available. Thus, we need to continue to be cognizant of informed consent, test sensitivity, confidentiality, prenatal diagnosis, preimplantation genetic screening, and public health concerns regarding testing.
Original language | English (US) |
---|---|
Pages (from-to) | 37-46 |
Number of pages | 10 |
Journal | Obstetrics and Gynecology Clinics of North America |
Volume | 37 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2010 |
Keywords
- Ashkenazi Jewish genetic screening
- Carrier screening
- Jewish genetic disorders
ASJC Scopus subject areas
- Obstetrics and Gynecology