Abstract
In this issue of Blood, Pangallo et al compare the changes in splicing outcome in patients with rare mutations in splicing factors U2AF1 and SRSF2 to the changes due to common hotspot mutations. Many of these rare mutations phenocopy the common ones, suggesting that they have been evolutionarily selected to alter splicing and drive pathogenicity by similar mechanisms.
Original language | English (US) |
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Pages (from-to) | 978-979 |
Number of pages | 2 |
Journal | Blood |
Volume | 135 |
Issue number | 13 |
DOIs | |
State | Published - Mar 26 2020 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology