Antipsychotic-induced weight gain: A comprehensive research synthesis

David B. Allison, Janet L. Mentore, Moonseong Heo, Linda P. Chandler, Joseph C. Cappelleri, Ming C. Infante, Peter J. Weiden

Research output: Contribution to journalArticlepeer-review

2251 Scopus citations


Objective: The purpose of this study was to estimate and compare the effects of antipsychotics - both the newer ones and the conventional ones - on body weight. Method: A comprehensive literature search identified 81 English- and non-English-language articles that included data on weight change in antipsychotic-treated patients. For each agent, a meta-analysis and random effects meta-regression estimated the weight change after 10 weeks of treatment at a standard dose. A comprehensive narrative review was also conducted on all articles that did not yield quantitative information but did yield important qualitative information. Results: Placebo was associated with a mean weight reduction of 0.74 kg. Among conventional agents, mean weight change ranged from a reduction of 0.39 kg with molindone to an increase of 3.19 kg with thioridazine. Among newer antipsychotic agents, mean increases were as follows: clozapine, 4.45 kg; olanzapine, 4.15 kg; sertindole, 2.92 kg; risperidone, 2.10 kg; and ziprasidone, 0.04 kg. Insufficient data were available to evaluate quetiapine at 10 weeks. Conclusions: Both conventional and newer antipsychotics are associated with weight gain. Among the newer agents, clozapine appears to have the greatest potential to induce weight gain, and ziprasidone the least. The differences among newer agents may affect compliance with medication and health risk.

Original languageEnglish (US)
Pages (from-to)1686-1696
Number of pages11
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - Nov 1999
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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