Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy

Inmaculada Tasset; René Drucker-Colín; José Peña; Ignacio Jimena; Pedro Montilla; Francisco Javier Medina; Isaac Túnez

doi:10.1007/s11064-010-0172-9

Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy

Inmaculada Tasset, René Drucker-Colín, José Peña, Ignacio Jimena, Pedro Montilla, Francisco Javier Medina, Isaac Túnez

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.

Original language	English (US)
Pages (from-to)	1182-1187
Number of pages	6
Journal	Neurochemical Research
Volume	35
Issue number	8
DOIs	https://doi.org/10.1007/s11064-010-0172-9
State	Published - Aug 2010
Externally published	Yes

Keywords

Antidepressive
Anxiety
Apoptosis
Cell death
Oxidative stress
Transcranial magnetic stimulation

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1007/s11064-010-0172-9

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abstract = "We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.",

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AU - Tasset, Inmaculada

AU - Drucker-Colín, René

AU - Peña, José

AU - Jimena, Ignacio

AU - Montilla, Pedro

AU - Medina, Francisco Javier

AU - Túnez, Isaac

PY - 2010/8

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AB - We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.

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Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy

Abstract

Keywords

ASJC Scopus subject areas

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