Yury Khelemsky, Karina Gritsenko, David Maerz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Antihistamines are a broad class of drugs, which can be further subdivided by their receptor specificity (H1 vs H2) and whether they cross the blood-brain barrier (first generation) or remain in the periphery (second generation). This chapter will focus on the first-generation H1antagonists commonly used in clinical practice for purposes of sedation, nauseal and vomiting prophylaxis, and roles in pain management.

Original languageEnglish (US)
Title of host publicationPain Medicine
Subtitle of host publicationAn Essential Review
PublisherSpringer International Publishing
Number of pages2
ISBN (Electronic)9783319431338
ISBN (Print)9783319431314
StatePublished - Jan 1 2017


  • Blood-brain barrier
  • Dosage
  • Drug interactions
  • Inverse agonist
  • Nausea
  • Pain management
  • Prophylaxis
  • Sedation
  • Side effects
  • Vomiting

ASJC Scopus subject areas

  • Medicine(all)


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