Antihelper T cell autoantibody in acquired agammaglobulinemia

A. Rubinstein, M. Sicklick, V. Mehra, F. S. Rosen, R. H. Levey

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A patient with acquired agammaglobulinemia had an antihelper T cell factor that was identified as an immunoglobulin of the IgG class. The factor specifically bound to the TH2-T cell subset and, in the presence of complement, abolished the helper effect of normal T cells. The antihelper T cell antibody preceded by several years the appearance of suppressor TH2+Ia+ T cells, at which time the clinical course rapidly deteriorated. Plasmapheresis resulted in lymphocytosis and reappearance of a functionally intact helper T cell population. It did not affect the suppressor cell. Conversely, total thymectomy resulted in a temporary disappearance of the TH2+Ia+ suppressor cells, but did not decrease the levels of the autoantibody to helper T cells. Neither of these treatments reversed the state of agammaglobulinemia.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalUnknown Journal
Issue number1
StatePublished - 1981

ASJC Scopus subject areas

  • General Medicine


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