TY - JOUR
T1 - Antibodies reactive with the cryptococcal capsular polysaccharide glucuronoxylomannan are present in sera from children with and without human immunodeficiency virus infection
AU - Abadi, Jacobo
AU - Pirofski, Liise Anne
N1 - Funding Information:
The studies reported were carried out in accordance with the human experimentation guidelines of the US Department of Health and Human Services and were approved by the Albert Einstein College of Medicine and Bronx-Lebanon Hospital Center institutional review boards. Grant support: NIH (AI-35370 to L.P.; CA-09173 to J.A.).
PY - 1999
Y1 - 1999
N2 - Antibodies reactive with the cryptococcal polysaccharide glucuronoxylomannan (GXM) are present in sera from both human immunodeficiency virus (HIV)-uninfected and -infected adults. However, the prevalence of these antibodies in US children is unknown. An antigen-capture ELISA was used to determine the presence, serotype specificity, isotype, and IgG subclass distribution of antibodies to GXM in sera from 27 HIV-uninfected and 34 HIV-infected children. The children were of similar age and socioeconomic background. IgG and IgM to GXM were present in sera from all children, although HIV-uninfected children had significantly higher titers. HIV-uninfected children had IgG1 and IgG2 to GXM and significantly greater IgG2 than in HIV-infected children. These findings of type-specific antibodies to GXM in early childhood suggest that exposure to or subclinical infection with Cryptococcus neoformans may be an early childhood event.
AB - Antibodies reactive with the cryptococcal polysaccharide glucuronoxylomannan (GXM) are present in sera from both human immunodeficiency virus (HIV)-uninfected and -infected adults. However, the prevalence of these antibodies in US children is unknown. An antigen-capture ELISA was used to determine the presence, serotype specificity, isotype, and IgG subclass distribution of antibodies to GXM in sera from 27 HIV-uninfected and 34 HIV-infected children. The children were of similar age and socioeconomic background. IgG and IgM to GXM were present in sera from all children, although HIV-uninfected children had significantly higher titers. HIV-uninfected children had IgG1 and IgG2 to GXM and significantly greater IgG2 than in HIV-infected children. These findings of type-specific antibodies to GXM in early childhood suggest that exposure to or subclinical infection with Cryptococcus neoformans may be an early childhood event.
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U2 - 10.1086/314953
DO - 10.1086/314953
M3 - Article
C2 - 10438394
AN - SCOPUS:0032825567
SN - 0022-1899
VL - 180
SP - 915
EP - 919
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -