Abstract
Introduction: The optimal Anti-VEGF (vascular endothelial growth factor) and Anti-EGFR (epithelial growth factor receptor) antibody regimen to combine with chemotherapy in the first-line treatment for metastatic colorectal cancer remains to be better defined. Results from randomized controlled trials are variable. Methods: A meta-analysis was performed by searching PubMed, Cochrane Registry, major oncology conferences proceedings until February 2010 for randomized controlled trials of Anti-VEGF and Anti-EGFR in first-line treatment of metastatic colorectal cancer. Summary estimates of progression-free survival, overall survival, overall response rate and 60- day mortality were derived. Effect of k-ras status was stratified in trials involving Anti-EGFR. Results: Nine trials were included, including three anti-VEGF +/- chemotherapy, n=2422; four anti-EGFR +/- chemotherapy, n=4348 and two anti-VEGF with chemotherapy +/- anti-EGFR, n=1601. Adding anti-VEGF to chemotherapy showed a 20-30% risk reduction in disease progression and mortality, and a higher response rate. Benefit of anti-EGFR was seen only in κ-ras wild type patients with 20% reduction in disease progression and 10% reduction of mortality. Adding both antibodies to chemotherapy showed worse survival outcomes. Conclusion: Benefit of adding anti-VEGF in first-line metastatic colorectal cancer treatment is well pronounced. Combining anti-EGFR with chemotherapy showed significant increase in response rate and PFS in κ-ras wild type patients. Adding both antibodies to chemotherapy appeared inferior regardless of κ-ras status.
Original language | English (US) |
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Pages (from-to) | 282-289 |
Number of pages | 8 |
Journal | Current Cancer Therapy Reviews |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - Nov 2011 |
Externally published | Yes |
Keywords
- Anti-EGFR
- Anti-VEGF
- Meta-analysis
- Metastatic colorectal cancer
- Monoclonal antibody
ASJC Scopus subject areas
- Molecular Medicine
- Oncology
- Cancer Research