Anterograde transneuronal degeneration in the limbic system: Clinical-anatomic correlation

William C. Torch, Asao Hirano, Seymour Solomon

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


A 64-year-old man with diffuse atherosclerosis developed an organic mental syndrome, followed by hypothalamic symptoms. Autopsy showed an old large cystic infarct involving the left temporal lobe including the hippocampus, and atrophy of the ipsilateral fornix, mammillary body, hypothalamus, mammillothalamic tract, and the anterior thalamic nucleus. The clinical deterioration and pathologic findings may be explained by anterograde transneuronal degeneration within the limbic system following the infarction.

Original languageEnglish (US)
Pages (from-to)1157-1163
Number of pages7
Issue number12
StatePublished - Dec 1977

ASJC Scopus subject areas

  • Clinical Neurology


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