Anterior horn cell degeneration and Bunina-type inclusions associated with dementia

Michael Noel Hart, Pasquale A. Cancilla, Stephen Frommes, Asao Hirano

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


The ultrastructural features of Bunina type inclusions in the anterior horn cells of a patient dying of amyotrophic lateral sclerosis with dementia appear unique. The Bunina-type inclusions are electron dense aggregates containing, and surrounded by organelle-like membranes. These inclusions appear to be a special type of autophagic vacuole, possibly arising from altered mitochondria.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalActa neuropathologica
Issue number3
StatePublished - Jan 1977


  • Amyotrophic lateral sclerosis
  • Anterior horn cell degeneration
  • Autophagic vacuoles
  • Bunina inclusion
  • Mitochondrial alteration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Anterior horn cell degeneration and Bunina-type inclusions associated with dementia'. Together they form a unique fingerprint.

Cite this