Annular size and interaction with trans-catheter aortic valves for treatment of severe bicuspid aortic valve stenosis: Insights from the BEAT registry

Elisabetta Moscarella, Antonio Mangieri, Francesco Giannini, Didier Tchetchè, Won Keun Kim, Jan Malte Sinning, Uri Landes, Ran Kornowski, Ole De Backer, Georg Nickenig, Chiara De Biase, Lars Søndergaard, Federico De Marco, Francesco Bedogni, Marco Ancona, Matteo Montorfano, Damiano Regazzoli, Giulio Stefanini, Stefan Toggweiler, Corrado TamburinoSebastiano Immè, Giuseppe Tarantini, Horst Sievert, Ulrich Schäfer, Jörg Kempfert, Jochen Wöehrle, Azeem Latib, Paolo Calabrò, Massimo Medda, Maurizio Tespili, Antonio Colombo, Alfonso Ielasi

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Transcatheter aortic valve replacement (TAVR) is safe and feasible in patients with bicuspid aortic valve (BAV), but whether annular size may influence TAVR results in BAV patients remains unclear. We aimed at evaluating the impact of aortic annular size on procedural and clinical outcomes of BAV patients undergoing TAVR, as well as potential interactions between annular dimension and trans-catheter heart valve (THV) type (balloon-expandable (BEV) vs. self-expanding (SEV). Methods: BEAT is a multicenter registry of consecutive BAV stenosis undergoing TAVR. For this sub-study patients were classified according to annular dimension in small-annulus (area < 400 mm2 or perimeter <72 mm), medium-annulus (area ≥ 400 and < 575 mm2, perimeter ≥72 mm and< 85 mm), large-annulus (area ≥ 575 mm2 or perimeter ≥85 mm). Primary endpoint was Valve Academic Research Consortium-2 (VARC-2) device success. Results: 45(15.5%) patients had small, 132(45.3%) medium, and 114(39.2%) large annuli. Compared with other groups, patients with large annuli were more frequently male, younger, with higher body mass index, larger aortic valve area, higher rate of moderate-severe calcification, lower mean trans-aortic valve gradient and lower left ventricular ejection fraction. In large-annuli SEVs were associated with a lower VARC-2 device success (75.9% vs. 90.6%, p = 0.049) driven by a higher rate of paravalvular valvular leak (PVL) compared to BEVs (20.7% vs. 1.2%, p < 0.001). However, no differences in clinical outcomes were observed according to annular size nor THV type. Conclusions: TAVR in BAV patients is feasible irrespective of annular size. However in patients with large aortic annulus SEVs were associated with a significantly higher rate of PVLs compared to BEVs.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalInternational Journal of Cardiology
StatePublished - Feb 15 2022


  • Annulus dimensions
  • Balloon expandable valves
  • Bicuspid aortic valve
  • Self-expanding valve
  • Severe aortic stenosis
  • Trans-catheter valve replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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