Annexin A5 levels in midtrimester amniotic fluid: Association with intrauterine growth restriction

Peter Van Eerden, Xiao Xuan Wu, Cynthia Chazotte, Jacob H. Rand

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: The purpose of this study was to determine whether amniotic fluid levels of annexin A5 (AF-AnxA5) may be associated with intrauterine growth restriction (IUGR). Study design: Amniotic fluid was obtained in a cohort of pregnant patients (n = 172) undergoing amniocentesis at 15 to 24 weeks' gestation and annexin A5 (AnxA5) levels were determined with enzyme-linked immunosorbent assay (ELISA). Patients who developed IUGR were compared with the remainder of the cohort. Results: AF-AnxA5 levels significantly increased through gestation (P = .003). The mean level of AF-AnxA5 in IUGR patients (n = 15) was significantly higher (P = .028) than in the remainder of the cohort (n = 130). Elevated AF-AnxA5 > 20 ng/mL was associated with a relative risk of 3.5 for the development of IUGR (P = .023). Conclusion: AnxA5 is present in amniotic fluid and increases through gestation from 15 to 24 weeks. Elevated AF-AnxA5 levels were present in patients who developed IUGR. AF-AnxA5 may be a useful marker for identifying pregnancy abnormalities.

Original languageEnglish (US)
Pages (from-to)1371-1376
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - May 2006
Externally publishedYes


  • Amniotic fluid
  • Amniotic fluid (AF)
  • Annexin A5 (AnxA5)
  • Antiphospholipid syndrome (APS)
  • Intrauterine growth restriction (IUGR)
  • Placenta
  • Placental vascular complications
  • Pregnancy complications

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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