An unexpected bis-Ligation of S-nitrosothiols

Jiming Zhang; Hua Wang; Ming Xian

doi:10.1021/ja900370y

An unexpected bis-Ligation of S-nitrosothiols

Jiming Zhang, Hua Wang, Ming Xian

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfideiminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.

Original language	English (US)
Pages (from-to)	3854-3855
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	131
Issue number	11
DOIs	https://doi.org/10.1021/ja900370y
State	Published - Mar 25 2009
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja900370y

Cite this

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title = "An unexpected bis-Ligation of S-nitrosothiols",

abstract = "A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfideiminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.",

author = "Jiming Zhang and Hua Wang and Ming Xian",

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AB - A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfideiminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.

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An unexpected bis-Ligation of S-nitrosothiols

Abstract

ASJC Scopus subject areas

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